Molecular clocks and the puzzle of RNA virus origins

EC Holmes - Journal of virology, 2003 - Am Soc Microbiol
… of RNA viruses is that this is in fact what happened. The key to this hypothesis is that the
molecular clock dates discussed throughout this paper only relate to the RNA viruses currently …

Evolution of sex and the molecular clock in RNA viruses

L Chao - Gene, 1997 - Elsevier
… ratchet in RNA viruses. Data from studies of wild populations of RNA viruses are also …
how an observed pattern of molecular evolution (or the molecular clock) in wild populations …

Rates of molecular evolution in RNA viruses: a quantitative phylogenetic analysis

GM Jenkins, A Rambaut, OG Pybus… - Journal of molecular …, 2002 - Springer
… Maximum likelihood rates of nucleotide substitution were calculated and the molecular
clock tested for 50 RNA viruses using the single rate dated tip (SRDT) model of sequence …

Molecular clock of viral evolution, and the neutral theory.

T Gojobori, EN Moriyama… - Proceedings of the …, 1990 - National Acad Sciences
… Since we now have a better understanding of evolutionary features of RNA viruses, we
focus our attention mainly on RNA viruses. In particular, we examine the rates of base …

The modern molecular clock

L Bromham, D Penny - Nature Reviews Genetics, 2003 - nature.com
… In this review we discuss the history of the molecular clock and … of a molecular clock (a
relatively constant rate of molecularRNA viruses provide an extreme example: they copy their …

Molecular evolution of viruses;'trees','clocks' and 'modules'

A Gibbs - Journal of Cell Science, 1987 - journals.biologists.com
… However, there is evidence that viral gene ‘molecular clocks’ do not always keep time consistently
over … Relation between genomic and capsid structures in RNA viruses. Nucl. Acid Res. …

Time-dependent rate phenomenon in viruses

P Aiewsakun, A Katzourakis - Journal of virology, 2016 - Am Soc Microbiol
… of DNA and RNA viruses might not be as clear as previously thought. In this study, we collected
396 … Our results provide a guideline for further improvement of the molecular clock. As a …

Reconstructing the evolutionary history of RNA viruses using relaxed molecular clocks

JO Wertheim - 2009 - search.proquest.com
… of emerging RNA viruses using relaxed molecular clocks. In … monkeys and their simian
immunodeficiency viruses (SIVs). A … In Appendix C, I use similar relaxed molecular clock dating …

Evolution of RNA viruses

D Zimmern - RNA genetics, 2018 - taylorfrancis.com
… fossil record is available with which to calibrate the molecular clock. Thus, protein
sequence comparisons cannot settle the question of antiquity of genes now found on …

Does the VP1 gene of foot-and-mouth disease virus behave as a molecular clock?

SF Elena, F González-Candelas, A Moya - Journal of molecular evolution, 1992 - Springer
… The results obtained indicate that a constant rate model, ie, a molecular clock, seems to be
the … We discuss the possibility that this evolution of RNA viruses was due to episodic positive …