Molecular determinants and mechanism for antibody cocktail preventing SARS-CoV-2 escape

Z Ku, X Xie, E Davidson, X Ye, H Su… - Nature …, 2021 - nature.com
… In summary, we report the molecular determinants and mechanism for a mAb cocktail that
prevents SARS-CoV-2 viral escape mutations. We also identified an epitope combination …

Analysis of a therapeutic antibody cocktail reveals determinants for cooperative and broad ebolavirus neutralization

P Gilchuk, CD Murin, JC Milligan, RW Cross, CE Mire… - Immunity, 2020 - cell.com
antibody cooperativity to develop a therapeutic mAb cocktail against Ebola virus. We
systematically analyzed the antibody … that in a two-antibody cocktail, molecular mimicry was a …

Molecular determinants of human neutralizing antibodies isolated from a patient infected with Zika virus

Q Wang, H Yang, X Liu, L Dai, T Ma, J Qi… - Science translational …, 2016 - science.org
antibodies bound to different viral epitopes, suggesting that these antibodies could be used
as a therapeutic cocktail… the potential of these antibodies to elicit antibody-dependent cellular …

An Immunodominant Epitope-Specific Monoclonal Antibody Cocktail Improves Survival in a Mouse Model of Staphylococcus aureus Bacteremia

H Zeng, J Zhang, X Song, J Zeng… - The Journal of …, 2021 - academic.oup.com
… Furthermore, we will study the mechanism of the mAb cocktail in a variety of disease models
and will also prepare the immunodominant epitope–specific humanized antibody or the …

[HTML][HTML] Molecular properties of human IgG subclasses and their implications for designing therapeutic monoclonal antibodies against infectious diseases

V Irani, AJ Guy, D Andrew, JG Beeson… - Molecular …, 2015 - Elsevier
Monoclonal antibodies are being developed as therapeutics to complement drugs and
vaccines or to fill the gap where no drugs or vaccines exist. These therapeutic antibodies (ThAb) …

Severe acute respiratory syndrome coronavirus 2 targeted antibodies cocktail and B cell receptor interplay: interventions to trigger vaccine development

K Haneef, R Saleem, MSI Khan… - Exploration of …, 2021 - explorationpub.com
… Nevertheless, considering therapeutic challenges in the context of the new coronavirus
pandemic, this review addresses the molecular mechanism of the immune activation and …

[HTML][HTML] ZRC3308 monoclonal antibody cocktail shows protective efficacy in Syrian hamsters against SARS-CoV-2 infection

PD Yadav, SK Mendiratta, S Mohandas, AK Singh… - Viruses, 2021 - mdpi.com
… a monoclonal antibody (mAb) cocktail (ZRC-… cocktail demonstrated effective prophylactic
and therapeutic activity against SARS-CoV-2 infection in Syrian hamsters. The antibody cocktail

… with different Pf AMA1 alleles in sequence induces clonal imprint humoral responses that are similar to responses induced by the same alleles as a vaccine cocktail …

KA Kusi, BW Faber, M van der Eijk, AW Thomas… - Malaria journal, 2011 - Springer
antibodies to epitopes that are common to all antigens was tested in this study. Antibodies
to … of induced cross-strain antibodies in comparison with antibodies induced by a multi-allele …

Two-mAb cocktail protects macaques against the Makona variant of Ebola virus

X Qiu, J Audet, M Lv, S He, G Wong, H Wei… - Science translational …, 2016 - science.org
… The human-mouse chimeric monoclonal antibody (mAb) cocktail ZMapp, previously shown
to be … We show that a two-antibody cocktail, MIL77E, is fully protective in NHPs when …

Enhanced radioimmunotherapeutic efficacy of a monoclonal antibody cocktail against SMMC-7721 human hepatocellular carcinoma

YQ Song, GF Wang, XL Dai, H Xie - Cell Research, 1998 - nature.com
… each antibody alone after two weeks. Tab 1 summarized the percentage of growth inhibition
of the MAb cocktail in comparison with that of each individual antibody. The MAb cocktail