… For the molecular mechanism, the cells isolated from the tumor of treated mice showed a
significant decrease in the B-cell lymphoma 2 (BCL2)/ BCL2-associated X protein (BAX) ratio, …

… The focus of the present review is on the antimetastatic efficacy of one such nutraceutical …
detailed possible mechanisms that contribute to the strong antimetastatic efficacy of silibinin. …

… is one of the mechanism for chemotherapy resistance in … NF-κB pathway can increase
the efficacy of cancer therapy. … molecular mechanisms for anti-invasive and anti-metastatic …

… studies, such as MMPIs, have failed to demonstrate their efficacy in clinical trials. Although
the present outlook on antimetastatic therapy is extremely disappointing, it is believed that the …

… In addition, secondary efficacy analyses showed that ZOL produced a significantly lower …
Owing to the proven efficacy of PAM at the time, the pivotal trial of ZOL in patients with …

… The inclusion of anti-metastatic agents in new generation … Increasing insights into the
molecular mechanisms of malignant … of cancer cells to maximize efficacy (bottom right). …

… -time monitoring of systemic-therapy efficacy presents new possibilities to evaluate targeted
… However, the antimetastatic effect of heparin is not a result of its anticoagulant activity but …

… MMP inhibitors failed to show strong signals of efficacy 27,28 . In addition, the … anti-metastatic
agents for which promising preclinical activity has not been translated into clinical efficacy …

… During the last decade the molecular mechanisms that are responsible for the
development of bone metastasis have been gradually illuminated. It appears that the bone …

The mechanism of metastasis is a complex set of events that build upon each other to
achieve successful growth in organ sites beyond the primary tumor. The cumulative events for …