12 天前 - … The hallmark of COVID-19 pathogenesis is the cytokine storm with elevated levels
of IL-1, IL-6, TNF-α, and GM-CSF [4]; all of these cytokines are produced by human MCs, as …

21 天前 - … precise molecular mechanism underlying cytokine storm … as a pivotal factor driving
cytokine storm onset in severe … insights into the molecular mechanisms underlying severe …

21 天前 - … Vasculopathy generally, and endothelial dysfunction, hypercoagulability, and
microthrombi in particular, can be induced by cytokine storms following infection and is a common …

24 天前 - … of inflammatory cytokines, the induction of hypoxia, and the triggering of cytokine
storms. … These findings suggest further research into the molecular mechanisms involved in …

24 天前 - … Top biological pathways were pathogen induced cytokine storm signalling (P FDR
=3.2x10 -48 ), hepatic fibrosis (P FDR =1.3x10 -47 ), and neutrophil degranulation (P FDR =…

27 天前 - … -viral response, and secretion of cytokines and chemokines. STC-15, a first in class
small molecule inhibitor of METTL3 developed by Storm Therapeutics, demonstrated in pre-…

28 天前 - Osteoporosis is a common bone metabolic disease that causes a heavy social burden
and seriously threatens life. Improving osteogenic capacity is necessary to correct bone …

29 天前 - … Furthermore, it can exacerbate tissue damage and contribute to the cytokine
storm. Understanding the mechanisms and consequences of SARS-CoV-2 Spike Protein 1-…

32 天前 - … mechanisms by which SARS-CoV-2 induces AVDS and subsequently MIS. Key
materials include molecular … severe endothelial dysfunction, cytokine storms, and mitochondrial …

34 天前 - … Similarly, in vitro studies do not accurately represent COVID-19 in vivo; nevertheless,
our model recreates the inflammation burden of the “cytokine storm” in the systemic …