Pathophysiological subtypes of Alzheimer's disease based on cerebrospinal fluid proteomics

BM Tijms, J Gobom, L Reus, I Jansen, S Hong… - Brain, 2020 - academic.oup.com
… Finally, we compared subtypes on neuropathological measures that were available for a …
of proteomic subtypes over time for a subset of individuals who had longitudinal proteomics

[HTML][HTML] Cerebrospinal fluid proteomics in patients with Alzheimer's disease reveals five molecular subtypes with distinct genetic risk profiles

BM Tijms, EM Vromen, O Mjaavatten, H Holstege… - Nature aging, 2024 - nature.com
… Here we define AD molecular subtypes using mass spectrometry proteomics in cerebrospinal
fluid, … These AD subtypes had alterations in protein levels that were associated with distinct …

High‐throughput proteomics of breast cancer interstitial fluid: identification of tumor subtype‐specific serologically relevant biomarkers

T Terkelsen, M Pernemalm, P Gromov… - Molecular …, 2021 - Wiley Online Library
… explored the proteome of proximal breast fluids with gel-based proteomics coupled with …
In the course of these studies, we have generated several representative proteome datasets, …

Large-scale cerebrospinal fluid proteomic analysis in Alzheimer's disease patients reveals five molecular subtypes with distinct genetic risk profiles

BM Tijms, EM Vromen, O Mjaavatten, H Holstege… - medRxiv, 2023 - medrxiv.org
… to define AD molecular subtypes by mass spectrometry proteomics in cerebrospinal fluid (CSF…
Cluster analyses of AD individuals on these 1058 proteins revealed five subtypes: subtype

[HTML][HTML] Functional proteomics outlines the complexity of breast cancer molecular subtypes

A Gámez-Pozo, L Trilla-Fuertes, J Berges-Soria… - Scientific Reports, 2017 - nature.com
… In this study, a new subtype of breast cancer was identified using a proteomics approach.
The clinical classification of breast cancer does not fully reflect cancer heterogeneity; thus, …

Approaching clinical proteomics: current state and future fields of application in fluid proteomics

R Apweiler, C Aslanidis, T Deufel… - Clinical chemistry and …, 2009 - degruyter.com
… for body fluid proteomics, like any other clinical laboratory … on fluid proteomics and suggest
procedures for sample preparation and standardization of protocols for analysis of body fluids

Proteomics of human biological fluids for biomarker discoveries: technical advances and recent applications

L Dayon, O Cominetti, M Affolter - Expert review of proteomics, 2022 - Taylor & Francis
… We provide examples of promising findings obtained in different biological fluid sample …
the terms ‘proteomics’ with different biological fluids (eg. ‘plasma’ or ‘cerebrospinal fluid’ or ‘urine’…

Blood proteomics to identify AD CSF molecular subtypes

BM Tijms, CE Teunissen, J Gobom, L Shi… - Alzheimer's & …, 2023 - Wiley Online Library
molecular subtypes in Alzheimer’s disease (AD) using cerebrospinal fluid (CSF) proteomics:
one subtype … second subtype was characterised by innate immune activation and the third …

[HTML][HTML] Proteomic profiling of extracellular vesicles allows for human breast cancer subtyping

S Rontogianni, E Synadaki, B Li, MC Liefaard… - Communications …, 2019 - nature.com
… that proteome profiles of EVs secreted by different breast cancer cell lines are highly indicative
of their respective molecular subtypes, even more so than the proteome … body fluids could …

Multipronged quantitative proteomics reveals serum proteome alterations in breast cancer intrinsic subtypes

A Gajbhiye, R Dabhi, K Taunk… - … of proteomics, 2017 - Elsevier
… it encompasses four major molecular subtypes. As breast … Numerous quantitative proteomic
tools have been employed … as the ductal lavage fluids, saliva, nipple aspirate fluids (NAFs), …