Phase 2/3 trial of molnupiravir for treatment of Covid-19 in nonhospitalized adults

Y Caraco, GE Crofoot, PA Moncada… - NEJM …, 2022 - evidence.nejm.org
… this phase 2 study and its companion trial in patients hospitalized with Covid-19, 29 molnupiravir
was … The subsequent phase 3 component of this study sought to further assess whether …

Efficacy and safety of molnupiravir for the treatment of SARS-CoV-2 infection: a systematic review and meta-analysis

JJ Malin, S Weibel, H Gruell… - Journal of …, 2023 - academic.oup.com
… Our analysis does not support routine use of molnupiravir for COVID-19 treatment in … to
the study protocols (WHO scale 23). Another small Phase 3 single-centre study from China …

Molnupiravir for the treatment of COVID-19 in immunocompromised participants: efficacy, safety, and virology results from the phase 3 randomized, placebo-controlled …

MG Johnson, JM Strizki, ML Brown, H Wan… - Infection, 2023 - Springer
… and received molnupiravir 800 mg twice daily for 5 days for the treatment of … phase 2/3
randomized, double-blind, placebo-controlled trial that evaluated molnupiravir for the treatment

Molnupiravir, an oral antiviral treatment for COVID-19

W Fischer, JJ Eron Jr, W Holman, MS Cohen, L Fang… - MedRxiv, 2021 - medrxiv.org
… was designed to evaluate the antiviral efficacy of molnupiravir and was not powered to …
However, a Phase 2/3 study is ongoing to evaluate the effect of molnupiravir on symptom duration …

Molnupiravir in COVID-19: A systematic review of literature

AK Singh, A Singh, R Singh, A Misra - Diabetes & Metabolic Syndrome …, 2021 - Elsevier
Phase 2/3 studies showed molnupiravir effectiveness in mild … Molnupiravir initially emerged
as a possible treatment of … in this study and was found to be lowest in molnupiravir 800 mg …

Molnupiravir for oral treatment of Covid-19 in nonhospitalized patients

A Jayk Bernal, MM Gomes da Silva… - … England Journal of …, 2022 - Mass Medical Soc
… The phase 3 component of MOVe-OUT, a phase 23, double-blind, parallel-group,
randomized, placebo-controlled trial evaluating the safety and efficacy of molnupiravir in …

Molnupiravir plus usual care versus usual care alone as early treatment for adults with COVID-19 at increased risk of adverse outcomes (PANORAMIC): an open-label …

CC Butler, FDR Hobbs, OA Gbinigie, NM Rahman… - The Lancet, 2023 - thelancet.com
Trials of molnupiravir have previously been done in largely unvaccinated participants …
Our trial provides an estimate of the effectiveness of molnupiravir in a multiply vaccinated …

Effect of molnupiravir on biomarkers, respiratory interventions, and medical services in COVID-19: a randomized, placebo-controlled trial

MG Johnson, A Puenpatom, PA Moncada… - Annals of internal …, 2022 - acpjournals.org
molnupiravir for the treatment of mild to moderate COVID-19 based on clinical markers and
the need for respiratory interventions and medical services from the phase … ) was a phase 2/3

A phase 2a clinical trial of molnupiravir in patients with COVID-19 shows accelerated SARS-CoV-2 RNA clearance and elimination of infectious virus

WA Fischer, JJ Eron Jr, W Holman, MS Cohen… - Science translational …, 2021 - science.org
… In a ferret model of SARS-CoV-2 infection, molnupiravir treatment completely blocked …
However, a phase 2/3 study is ongoing to evaluate the effect of molnupiravir on symptom duration …

Impact of molnupiravir treatment on patient-reported COVID-19 symptoms in the phase 3 MOVe-OUT trial: a randomized, placebo-controlled trial

Y Guan, A Puenpatom, MG Johnson… - Clinical Infectious …, 2023 - academic.oup.com
… To assess the impact of molnupiravir treatment on COVID-19 … -reported symptoms data from
the phase 3 component of MOVe-… Phase 2/3 trial of molnupiravir for treatment of COVID-19 in …