Real-world experience of the comparative effectiveness and safety of molnupiravir and nirmatrelvir/ritonavir in high-risk patients with COVID-19 in a community setting

Y Mutoh, T Umemura, T Nishikawa, K Kondo, Y Nishina… - Viruses, 2023 - mdpi.com
… Considering that early treatment initiation has the potential to prevent disease progression,
molnupiravir (MOV) and nirmatrelvir/ritonavir (NMV/r) were developed as oral antiviral agents…

Comparison of safety and efficacy between Nirmatrelvir-ritonavir and molnupiravir in the treatment of COVID-19 infection in patients with advanced kidney disease: a …

WM Chu, EYF Wan, ZCT Wong, AR Tam… - …, 2024 - thelancet.com
… We performed a retrospective territory-wide observational study evaluating the safety and
efficacy of nirmatrelvir-ritonavir when compared with molnupiravir in the treatment of patients …

Molnupiravir for oral treatment of Covid-19 in nonhospitalized patients

A Jayk Bernal, MM Gomes da Silva… - … England Journal of …, 2022 - Mass Medical Soc
… trial to evaluate the efficacy and safety of treatment with molnupiravir started within 5 days
… 800 mg of molnupiravir or placebo twice daily for 5 days. The primary efficacy end point was …

Molnupiravir plus usual care versus usual care alone as early treatment for adults with COVID-19 at increased risk of adverse outcomes (PANORAMIC): an open-label …

CC Butler, FDR Hobbs, OA Gbinigie, NM Rahman… - The Lancet, 2023 - thelancet.com
… the findings of six trials of molnupiravir compared with either standard of care or placebo.
These reviews suggested that molnupiravir reduces the frequency of hospital admissions in …

Optimal dose and safety of molnupiravir in patients with early SARS-CoV-2: a Phase I, open-label, dose-escalating, randomized controlled study

SH Khoo, R Fitzgerald, T Fletcher… - Journal of …, 2021 - academic.oup.com
… AGILE is a Phase Ib/IIa platform for rapidly evaluating COVID-19 treatments. In this trial (NCT04746183)
we evaluated the safety and optimal dose of molnupiravir in participants with …

An updated practical guideline on use of molnupiravir and comparison with agents having emergency use authorization for treatment of COVID-19

AK Singh, A Singh, R Singh, A Misra - Diabetes & Metabolic Syndrome …, 2022 - Elsevier
… ) that was planned to assess efficacy and safety of molnupiravir in 1433 non-hospitalized …
by the independent data safety monitoring board due to excessive benefit in molnupiravir arm …

Real-world effectiveness of molnupiravir and nirmatrelvir plus ritonavir against mortality, hospitalisation, and in-hospital outcomes among community-dwelling …

CKH Wong, ICH Au, KTK Lau, EHY Lau, BJ Cowling… - The Lancet, 2022 - thelancet.com
… Within the case-control study design, patients with COVID-19 received molnupiravir or
nirmatrelvir plus ritonavir treatment in the outpatient setting before the reference date, which was …

Molnupiravir as an early treatment for COVID-19: a real life study

M Pontolillo, C Ucciferri, P Borrelli, M Di Nicola… - Pathogens, 2022 - mdpi.com
… Below, we report our experience in the use of molnupiravir, the first … in the treatment of
patients with COVID-19. The aim of the study is to verify the efficacy and tolerability of molnupiravir

Comparative efficacy and safety of nirmatrelvir/ritonavir and molnupiravir for COVID‐19: A systematic review and meta‐analysis

B Amani, A Akbarzadeh, B Amani… - Journal of Medical …, 2023 - Wiley Online Library
… the efficacy and safety of nirmatrelvir/ritonavir (Paxlovid) with molnupiravir in the treatment of
… a significant difference between nirmatrelvir/ritonavir and molnupiravir in terms of all-cause …

Effectiveness of nirmatrelvir/ritonavir and molnupiravir in non-hospitalized adults with COVID-19: systematic review and meta-analysis of observational studies

YM Mesfin, JE Blais, KT Kibret… - Journal of …, 2024 - academic.oup.com
… Objective: To determine the effectiveness of nirmatrelvir/ritonavir and molnupiravir among …
of nirmatrelvir/ritonavir or molnupiravir compared to no antiviral drug treatment for COVID-19 in …