Mucosal immunization with an adenoviral vector vaccine confers superior protection against RSV compared to natural immunity

C Maier, J Fuchs, P Irrgang, MH Wißing… - Frontiers in …, 2022 - frontiersin.org
… After proving that Ad-F+Ad-IL-1β is an effective vaccine candidate that establishes systemic
and mucosal immunity, we compared its immunogenicity profile and protective efficacy to …

Adenoviral vectors for mucosal vaccination against infectious diseases

M Santosuosso, S McCormick, Z Xing - Viral immunology, 2005 - liebertpub.com
… of mucosal immunity suggests that mucosal vaccination is far … the use of adenoviral vector
at mucosal sites for infectious … models have suggested that adenoviral vectors are effective in …

Systemic and mucosal immunity in mice elicited by a single immunization with human adenovirus type 5 or 41 vector‐based vaccines carrying the spike protein of …

X Guo, Y Deng, H Chen, J Lan, W Wang, X Zou… - …, 2015 - Wiley Online Library
… route of rAd vector delivery critically impacted both systemic and mucosal immunity. In
particular… T-lymphocyte responses among the systemic and mucosal compartments. In contrast, ig …

Mucosal immunity and protection after intranasal immunization with recombinant adenovirus expressing herpes simplex virus glycoprotein B

WS Gallichan, DC Johnson, FL Graham… - Journal of Infectious …, 1993 - academic.oup.com
… Since parenteral immunization with an adenovirus vector expressing gB … mucosal
immunization would stimulate mucosal immune responses and provide protection at the mucosal

Methods and clinical development of adenovirus-vectored vaccines against mucosal pathogens

S Afkhami, Y Yao, Z Xing - Molecular Therapy-Methods & Clinical …, 2016 - cell.com
adenoviral vectors including nonhuman adenoviral vectors … In this review, we discuss the
latest adenoviral technologies and … of adenoviral-vectored vaccines in mucosal immunization …

Respiratory mucosal immunization with adenovirus gene transfer vector induces helper CD4 T cell‐independent protective immunity

J Mu, M Jeyanathan, CR Shaler… - The journal of gene …, 2010 - Wiley Online Library
… However, respiratory mucosal vaccination in humans may require consideration of the use
adenoviral vectors for enhanced safety (ie different from the conventional adenoviral vector

ChAdOx1‐S adenoviral vector vaccine applied intranasally elicits superior mucosal immunity compared to the intramuscular route of vaccination

M Cokarić Brdovčak, J Materljan… - European journal of …, 2022 - Wiley Online Library
… titer in the sera and in the respiratory mucosa. Bronchoalveolar lavage from intranasally
immunized … application of adenoviral vector ChAdOx1-S induces superior mucosal immunity and …

Recombinant viruses as vectors for mucosal immunity

CD Morrow, MJ Novak, DC Ansardi, DC Porter… - … Pathogenesis, Immunity …, 1999 - Springer
… The use of adenovirus as a mucosal vaccine vector is attractive because serotypes 4 and
7 have been proven safe and effective when administered to millions of military recruits over …

Protective mucosal immunity against SARS-CoV-2 after heterologous systemic prime-mucosal boost immunization

D Lapuente, J Fuchs, J Willar, A Vieira Antão… - Nature …, 2021 - nature.com
… with adenovirus 5 … mucosal immunity in mice. In contrast to two intramuscular applications
of an mRNA vaccine, intranasal boosts with adenoviral vectors induce high levels of mucosal

Impact of systemic or mucosal immunity to adenovirus on Ad-based Ebola virus vaccine efficacy in guinea pigs

JS Richardson, MC Abou, KN Tran… - The Journal of …, 2011 - academic.oup.com
… , and conjunctivitis in humans while inducing a strong innate and adaptive immune response,
making adenovirus (Ad)-based vectors an attractive vaccine platform [20]. Recombinant …