… , have been shown independently to be associated with multidrug-resistan-… mdrl gene
also express P-glycoprotein, and that cDNAs encoding P-glycoprotein'cross-hybridize with mdrl …

… Although the natural substrate for the mdrl gene encoded P-glycoprotein is not yet known,
these expression data suggest that the P-glycoprotein drug efflux pump plays a role in the …

… multidrug resistance in these model … multidrugresistance phenotype and its genetic basis
and presents the evidence that overexpression of P-glycoprotein causes multidrug resistance. …

… multidrug resistance to natural product drugs, with a specific focus on the ways in which this
form of multidrug resistance … tissues that normally express the MDRl gene, such as cancer of …

… cell lines and in genetransfer … mdrl mRNA levels and the degree of multidrug resistance (9,
19). In addition, we have shown that increased mdrl gene expression can occur prior to gene …

… gene contributes to multidrug resistance in many human cancers. Thus, evaluation of MDR1
gene … The human multidrug resistance (mdrl) gene, cDNA cloning and transcription initiation…

… one ofthe amplified mdr sequences and designated … the multidrugresistant cell lines (2).
We now examine expression of the mdrl mRNA during the development of multidrug resistance …

… and ex pressed in MDR cells (3, 4), including the human MDRl gene which plays a major
role in the acquisition and maintenance of the MDR phenotype (3). This gene was cloned, …

… the human MDRl gene, also confer the MDR phenotype. Transfected cells show resistance
to … sites of the mdrl gene abolish its ability to confer multidrug resistance. Mol Cell Biol 1989; …

… multidrug-resistance phenotype.12,13 We have used cDNAs encoding the human mdrl gene
to measure the levels of mdrl … Our studies have shown that the mdrl gene is expressed at …