… Abstract Multidrug resistance (MDR) is the protection of a tumor cell population against
numerous drugs differing in chemical structure and mechanisms of influence on the cells. MDR is …

… Our understanding of MDR in tumor cells has been limited by our lack of knowledge of the …
in tumor cells. This article reviews the MDR literature to explore the changes in the cell biology …

… This book deals with a particular type of resistance in tumor cells that represents a single …
drug resistance. This type of resistance, known as multidrug or pleiotropic drug resistance, is …

… Multidrug resistance in animal cells is defined as the simultaneous resistance to a variety
of … One type of multidrug resistance is characterized by the decreased accumulation of …

… However, while at-MDR, like Pgp-MDR, … in tumor cell lines, its existence in the tumors ofdrug
resistant patients remains to … topo II forms of MDR have now been described experimentally, …

… cytotoxicity of LAK and CIK cells remains controversial and seems to be complex (27–29).
In this study, the cytotoxic effect of CIK cells against the tumor cells can be significantly …

… use of MDR modulators in combination therapy, allowing the restoration of cytotoxic activity
… clinical cytostatics towards resistant tumor cells. Keywords: multidrug resistance, antitumor …

… its multidrug resistant (MDR), P-glycoprotein (P-gp) overexpressing variant, HL-60R. HL-60R
exhibits resistance … , including cisplatin, not related to the multidrug transporter (4). We have …

Induction by verapamil of a rapid increase in ATP consumption in multidrugâ•’resistant
tumor cells … in drug-resistant P388 tumor cells following incubation with calcium …

… We have generated rat and murine monoclonal antibodies against multidrug resistance-…
multidrug re sistance of human tumor cells. The antibodies were raised against two different …