… Multidrug resistance (MDR) is a crucial issue in the treatment of cancer cells that protect
themselves by overexpression of active efflux transporters (AETs). AET expression maintains the …

… serve as energy-transducing components of tripartite assemblies that actively efflux drugs
and other … for the main classes of multi-drug transporters and their higher-order assemblies. …

… A total of 15 family members can function as drug-efflux pumps, and have been implicated in
… drug transporters are located in the plasma membrane, where they engage in active efflux …

… drug transporters … multidrug resistance, whereas others mediate efflux with a high specificity.
On the basis of similarities in size and secondary structure, the secondary drug transporters …

… However, if active efflux is not the mechanism of MDR, what then is the mechanism?
Furthermore, if P-gp does not function as a multidrug transporter, then what is the function of the …

… to the potential role of these efflux transporters in intractable epilepsy. Nevertheless, taken
the enormous experimental and clinical interest in multidrug transporters, it seems very likely …

… for the multidrug resistance of bacteria is the expression of multidrug efflux transporters,
which … AcrB and its homologues are the major multidrug efflux transporters in Gram-negative …

… eukaryotic-specific family in which cellular multidrug efflux pumps occur. One, the … efflux,
but the MFS, RND, MATE and DMT superfamilies include members that are secondary carriers, …

… pump consists of three components: the inner membrane transporter, the outer … multidrug
transporters from eukaryotic cells and Gram-positive bacteria, the inner membrane transporters …

… Composed of one or more protein components, these multidrug efflux pumps traverse the
cell membrane, binding and actively pumping out a broad range of noxious agents—in some …