Rutin: A flavonoid as an effective sensitizer for anticancer therapy; insights into multifaceted mechanisms and applicability for combination therapy

A Satari, S Ghasemi, S Habtemariam… - Evidence‐Based …, 2021 - Wiley Online Library
Rutin is a unique antioxidant flavonoid that is mainly found in fruit, vegetables, cereals, and
many other plant‐based human diets. This review aims to highlight the in vitro anticancer

[HTML][HTML] The multifaced role of STAT3 in cancer and its implication for anticancer therapy

M Tolomeo, A Cascio - International journal of molecular sciences, 2021 - mdpi.com
… This depends on the ability of STAT3 to suppress anticancer immune cells and to activate
cancer promoting immune cells. Therefore, therapies based on STAT3 modulators can not …

[HTML][HTML] The 26S proteasome is a multifaceted target for anti-cancer therapies

TA Grigoreva, VG Tribulovich, AV Garabadzhiu… - Oncotarget, 2015 - ncbi.nlm.nih.gov
… of anti-cancer therapy - via exploration of various combinations of proteasome inhibitors with
other anti-cancer drugs. Below, we mention several most popular therapeutic combinations …

Multifaceted Understandings of Cancer: A Review of Disease Mechanisms and Therapies

RS Pal, Y Pal, MVNL Chaitanya, R Babu… - … Cancer Therapy …, 2024 - ingentaconnect.com
… This review aims to explore the multifaceted nature of cancer, delve into the complexities
of its pathophysiology, and shed light on the diverse therapeutic strategies used in the current …

Multifaceted anticancer activity of BH3 mimetics: Current evidence and future prospects

M Opydo-Chanek, O Gonzalo, I Marzo - Biochemical pharmacology, 2017 - Elsevier
… In this regard, BH3 mimetics may lower normal tissue toxicity relative to conventional
anticancer therapies that interfere with general mechanisms including DNA synthesis, mitosis and …

A Multifaceted Challenge in Cancer Treatment

M Khatri, S Dhar, P Ven, A Singh - Asian Journal of …, 2024 - search.proquest.com
… of resistance to anticancer therapies continues to impede successful outcomes. Anticancer
resistance is a complex phenomenon that involves various pharmacological mechanisms, …

Multifaceted roles of copper ions in anticancer nanomedicine

S Yang, Y Song, Y Hu, HJ Chen… - Advanced Healthcare …, 2023 - Wiley Online Library
therapy, among which Cu‐based nanotherapeutic systems have received greater attention.
Herein, the multifaceted … kinds of tumor therapies including copper depletion therapy, copper‐…

[HTML][HTML] Anticancer therapy with HDAC inhibitors: mechanism-based combination strategies and future perspectives

R Jenke, N Reßing, FK Hansen, A Aigner, T Büch - Cancers, 2021 - mdpi.com
… Induction of apoptotic cell death represents one of the main mechanisms of anticancer
effects promoted by HDAC inhibitors [57,58,59,60,61]. Regarding apoptosis signaling in cancer …

Multiple roles and context-specific mechanisms underlying YAP and TAZ-mediated resistance to anti-cancer therapy

F Reggiani, G Gobbi, A Ciarrocchi… - … et Biophysica Acta (BBA …, 2020 - Elsevier
… In summary, YAP/TAZ have a central role in modulating response to many anti-cancer
therapies. For this reason, pharmacological inhibition of YAP/TAZ activity has been proposed to …

Enzymes involved in tumor-driven angiogenesis: A valuable target for anticancer therapy

B Ricciuti, J Foglietta, V Bianconi, A Sahebkar… - Seminars in Cancer …, 2019 - Elsevier
… Starting with Folkman’s initial observations in 1971, basic research continued to shed new
molecular insight into this multifaceted process, leading to the development of several anti-…