The NLRP3 inflammasome in acute myocardial infarction

S Toldo, A Abbate - Nature Reviews Cardiology, 2018 - nature.com
… evidence supporting the therapeutic value of NLRP3 inflammasome-targeted strategies in
… of the NLRP3 inflammasome in AMI and its consequences on adverse cardiac remodelling, …

NLRP3 inflammasome as a novel player in myocardial infarction

M Takahashi - International heart journal, 2014 - jstage.jst.go.jp
… of the NLRP3 inflammasomes and their activation, which results in processing and release of
IL-1β. The NLRP3 inflammasomes contain NLRP3 … The NLRP3 inflammasome activation is …

NLRP3 inflammasome in acute myocardial infarction

AG Mauro, A Bonaventura, E Mezzaroma… - Journal of …, 2019 - journals.lww.com
… The NLRP3 inflammasome is primed and triggered by locally released damage-associated …
role for NLRP3 in AMI and the available strategies to inhibit the effects of the inflammasome. …

Cell-specific roles of NLRP3 inflammasome in myocardial infarction

M Takahashi - Journal of Cardiovascular Pharmacology, 2019 - journals.lww.com
… , cardiac fibroblasts, and … NLRP3 inflammasome may be a potential target for the prevention
and therapy of MI. This review summarizes recent knowledge on NLRP3 inflammasome

Role of NLRP3 inflammasome in cardiac inflammation and remodeling after myocardial infarction

M Takahashi - Biological and Pharmaceutical Bulletin, 2019 - jstage.jst.go.jp
cardiac dysfunction and remodeling in rodent models of MI. Therefore, the regulation of NLRP3
inflammasome … role of NLRP3 inflammasome in the process of cardiac inflammation and …

The selective NLRP3-inflammasome inhibitor MCC950 reduces myocardial fibrosis and improves cardiac remodeling in a mouse model of myocardial infarction

R Gao, H Shi, S Chang, Y Gao, X Li, C Lv… - International …, 2019 - Elsevier
… damage and reduces heart fibrosis, improving cardiac remodeling, as … NLRP3 inflammasome
in heart tissue and suppresses the recruitment of inflammatory mediators in cardiac

Could NLRP3Inflammasome Be a Cardiovascular Risk Biomarker in Acute Myocardial Infarction Patients?

P Bullón, FJ Cano-García, E Alcocer-Gómez… - 2017 - liebertpub.com
… asymptomatic individuals with high risk of acute myocardial infarction (AMI). However, AMI
… We propose to evaluate the NLRP3inflammasome complex as a potential conventional …

Inhibition of the NLRP3 inflammasome limits the inflammatory injury following myocardial ischemia–reperfusion in the mouse

S Toldo, C Marchetti, AG Mauro, J Chojnacki… - International Journal of …, 2016 - Elsevier
… Successful reperfusion is the most effective strategy to reduce ischemic injury in acute
myocardial infarction (AMI). Ischemic injury, however, also triggers a secondary ischemia–…

Isofraxidin alleviates myocardial infarction through NLRP3 inflammasome inhibition

G Chen, X Song, D Lin, P Xu - Inflammation, 2020 - Springer
… Here in this study, we also demonstrated an increase of the NLRP3 inflammasome-related
proteins including NLRP3 and ASC in the heart tissue on the occurrence of MI as well as …

Immunomodulation of the NLRP3 inflammasome in atherosclerosis, coronary artery disease, and acute myocardial infarction

MJM Silvis, EJ Demkes, ATL Fiolet, M Dekker… - Journal of …, 2021 - Springer
… the role of the NLRP3 inflammasome in atherosclerosis, CAD, and myocardial I/R injury.
Furthermore, the current therapeutic approaches targeting the NLRP3 inflammasome and its …