Epigenetic regulation of adipose tissue expansion and adipogenesis by N6methyladenosine

R Wu, X Wang - Obesity Reviews, 2021 - Wiley Online Library
… function mutation leads to reduced body weight and fat mass. Transcriptome analyses in
combination with m 6 A-seq in mouse preadipocytes revealed that FTO targeted thousands of m …

The potential role of N6-methyladenosine (m6A) demethylase fat mass and obesity-associated gene (FTO) in human cancers

J Wang, L Chen, P Qiang - OncoTargets and therapy, 2020 - Taylor & Francis
N6-methyladenosine (m6A) demethylase fat mass and obesity-associated gene(FTO),
previously recognized to be related with obesity and diabetes, was gradually discovered to be …

N6-methyl-adenosine modification in messenger and long non-coding RNA

T Pan - Trends in biochemical sciences, 2013 - cell.com
… of a mammalian enzyme that removes m 6 A and the application of deep sequencing to
localize modification sites. The m 6 A demethylase fat mass and obesity associated protein (FTO…

Cerebroprotective Role of N6-Methyladenosine Demethylase FTO (Fat Mass and Obesity-Associated Protein) After Experimental Stroke

AK Chokkalla, S Jeong, SL Mehta, CK Davis… - Stroke, 2023 - Am Heart Assoc
… We and others have previously reported that experimental stroke in rodents triggers m 6 A
hypermethylation and a concomitant downregulation of m 6 A demethylase FTO (fat mass and …

FTO-dependent function of N6-methyladenosine is involved in the hepatoprotective effects of betaine on adolescent mice

J Chen, X Zhou, W Wu, X Wang, Y Wang - Journal of physiology and …, 2015 - Springer
… status of m 6 A mRNA methylation and expression of the fat mass and obesity-associated
gene (FTO), which exerted an oxidative demethylation activity targeting m 6 A residues in RNA. …

Fat mass and obesity associated (FTO)-mediated N6-methyladenosine modification of Krüppel-like factor 3 (KLF3) promotes osteosarcoma progression

HJ Shan, WX Gu, G Duan, HL Chen - Bioengineered, 2022 - Taylor & Francis
N6-methyladenosine (m6A) methylation is the most common and abundant methylation
modification of eukaryotic mRNAs, which is involved in tumor initiation and progression. The …

The N6methyladenosine (m6A) erasers alkylation repair homologue 5 (ALKBH5) and fat mass and obesity‐associated protein (FTO) are prognostic biomarkers in …

A Strick, F von Hagen, L Gundert, N Klümper… - BJU …, 2020 - Wiley Online Library
Objectives To comprehensively investigate the role of the N 6methyladenosine (m 6 A)
erasers ALKBH5 and FTO in clear cell renal cell carcinoma (ccRCC), other RCC subtypes, and …

[HTML][HTML] Fat mass and obesity-associated factor (FTO)-mediated N6-methyladenosine regulates spermatogenesis in an age-dependent manner

Y Wu, J Li, C Li, S Lu, X Wei, Y Li, W Xia, C Qian… - Journal of Biological …, 2023 - ASBMB
N6-methyladenosine (m6A) is the most prevalent reversible RNA modification in the mammalian
transcriptome. It has recently been demonstrated that m6A is crucial for male germline …

The beneficial effects of betaine on dysfunctional adipose tissue and N6-methyladenosine mRNA methylation requires the AMP-activated protein kinase α1 subunit

X Zhou, J Chen, J Chen, W Wu, X Wang… - The Journal of Nutritional …, 2015 - Elsevier
… These changes were also accompanied with decreased epididymal fat mass and improved
systemic insulin resistance, which was manifested by remarkably decreased circulating FFA …

Update on N6methyladenosine methylation in obesity‐related diseases

C Cheng, F Yu, G Yuan, J Jia - Obesity, 2024 - Wiley Online Library
… The regulatory mechanism of N6-methyladenosine (m6A) methylation. The writers are …
The m6A demethylation process is mainly mediated by erasers including fat mass- and obesity-…