N6-methyladenosine methyltransferase WTAP-stabilized FOXD2-AS1 promotes the osteosarcoma progression through m6A/FOXM1 axis

Z Ren, Y Hu, J Sun, Y Kang, G Li, H Zhao - Bioengineered, 2022 - Taylor & Francis
… target FOXM1 mRNA through m 6 A sites, forming a FOXD2-AS1/m 6 A/FOXM1 complex to
… which m 6 A-modified FOXD2-AS1 accelerates the osteosarcoma progression through m 6 A …

[HTML][HTML] m6A methyltransferase METTL3-mediated lncRNA FOXD2-AS1 promotes the tumorigenesis of cervical cancer

F Ji, Y Lu, S Chen, X Lin, Y Yu, Y Zhu, X Luo - Molecular Therapy …, 2021 - cell.com
… ) and N 6 -methyladenosine (m 6 A) methylation … FOXD2 adjacent opposite strand RNA 1
(FOXD2-AS1) modulates cervical cancer tumorigenesis. Results illuminated that FOXD2-AS1

[HTML][HTML] Novel insights into mutual regulation between N6-methyladenosine modification and LncRNAs in tumors

N Zhang, Y Sun, Z Mei, Z He, S Gu - Cancer Cell International, 2023 - Springer
… adjacent opposite strand RNA 1 (FOXD2-AS1) has … m 6 A-modified sites were found on the
3'-UTR of FOXD2-AS1, thus enhancing the stability of FOXD2-AS1 transcript, on which m 6 A …

[HTML][HTML] Novel insights into the multifaceted roles of m6A-modified LncRNAs in cancers: biological functions and therapeutic applications

J Tang, J Zhang, Y Lu, J He, H Wang, B Liu, C Tu… - Biomarker research, 2023 - Springer
N6-methyladenosine (m 6 A) is considered as the most common and important internal
transcript modification in several diseases like type 2 diabetes, schizophrenia and especially …

[HTML][HTML] Epigenetic deregulation in cancer: Enzyme players and non-coding RNAs

AA Farooqi, S Fayyaz, P Poltronieri, G Calin… - Seminars in cancer …, 2022 - Elsevier
… SETD2 mediated H3K36 trimethylation is implied in N6-methyladenosine (m6A) mRNA …
(B) DLX6-AS1 epigenetically inactivates CADM1 by enhancing the methylation at promoter …

[HTML][HTML] A review on the role of FOXD2-AS1 in human disorders

S Ghafouri-Fard, A Harsij, BM Hussen… - … -Research and Practice, 2024 - Elsevier
… LncRNA FOXD2 adjacent opposite strand RNA1 (FOXD2-AS1) … FOXD2-AS1 is an lncRNA
that is related to malignancies. It … Dysregulation of FOXD2-AS1 has an oncogenic impact, and …

[HTML][HTML] The chromatin-associated RNAs in gene regulation and cancer

J Tang, X Wang, D Xiao, S Liu, Y Tao - Molecular Cancer, 2023 - Springer
… The role of m 6 A on caRNAs in chromatin modification and transcriptional regulation To
date, N6-methyladenosine (m 6 A) has been the most abundant dynamic modification that has …

[HTML][HTML] The roles of N6-methyladenosine and its target regulatory noncoding RNAs in tumors: classification, mechanisms, and potential therapeutic implications

Z Liu, L Gao, L Cheng, G Lv, B Sun, G Wang… - … & Molecular Medicine, 2023 - nature.com
… the m6A modification of LncFOXD2-AS1, and FOXD2-AS1 binds to its target FOXM1 mRNA
to … WTAP binds to the m6A site of LncDLGAP1-AS1 to improve its stability, and DLGAP1-AS1

[HTML][HTML] Emerging role of RNA modification and long noncoding RNA interaction in cancer

L Yang, L Tang, Q Min, H Tian, L Li, Y Zhao… - Cancer Gene …, 2024 - nature.com
… In this review, we summarize N6-methyladenosine, 5-methylcytosine, and N7-… m6A
modification of KCNK15-AS1, enhancing the expression and stability of KCNK15-AS1 in PC cells. …

[HTML][HTML] Comprehensive analysis of the expression of N6-methyladenosine RNA methylation regulators in pulmonary artery hypertension

H Zheng, J Hua, H Li, W He, X Chen, Y Ji, Q Li - Frontiers in Genetics, 2022 - frontiersin.org
Background: Pulmonary arterial hypertension (PAH) is a progressive disease characterized
by pulmonary vascular remodeling. The development of PAH involves N6-methyladenosine (…