[HTML][HTML] METTL3 Contributes to Osteosarcoma Progression by Increasing DANCR mRNA Stability via m6A Modification

X Zhou, Y Yang, Y Li, G Liang, D Kang… - Frontiers in Cell and …, 2022 - frontiersin.org
Osteosarcoma (OS) is the most prevalent bone cancer among children and adolescents, with
relatively high mortality rates. RNA N6-methyladenosine (… in OS progression remain unclear…

[HTML][HTML] N6-methyladenosine-dependent signalling in cancer progression and insights into cancer therapies

F Tan, M Zhao, F Xiong, Y Wang, S Zhang… - Journal of Experimental …, 2021 - Springer
… The N6-methyladenosine (m6A) modification is a dynamic and reversible epigenetic …
Several studies have shown that m6A modification is dysregulated in the progression of multiple …

[HTML][HTML] N6-methyladenosine links RNA metabolism to cancer progression

D Dai, H Wang, L Zhu, H Jin, X Wang - Cell death & disease, 2018 - nature.com
N6-methyladenosine (m6A) is the most abundant mRNA modification. With the development
of antibody-based sequencing technologies and the findings of m6A-related “writers”, “…

FTO-Mediated N6-Methyladenosine Modification of KLF3 Promotes Osteosarcoma Progression

HJ Shan, WX Gu, G Duan, ZM Zhu, HL Chen - 2021 - researchsquare.com
N6-methyladenosine (m6A) methylation is the most common … progression. This study aims
to explore the functional role and regulatory mechanism of FTO in osteosarcoma progression. …

The roles of N6-methyladenosine methylation in the regulation of bone development, bone remodeling and osteoporosis

Y Li, L Meng, B Zhao - Pharmacology & therapeutics, 2022 - Elsevier
… These findings provided cues for the roles of YTHDF1-mediated m 6 A modification in
bone development and remodeling during bone ageing and the progression of osteoporosis. …

[HTML][HTML] WTAP promotes osteosarcoma tumorigenesis by repressing HMBOX1 expression in an m6A-dependent manner

S Chen, Y Li, S Zhi, Z Ding, W Wang, YI Peng… - Cell death & …, 2020 - nature.com
N6-methyladenosine (m 6 A) is the prominent dynamic mRNA modification, which is … by
which WTAP regulates the progression of osteosarcoma, we performed RNA-seq, m 6 A-seq in …

[HTML][HTML] Regulatory role of N6-methyladenosine (m6A) modification in osteoarthritis

G Zhai, L Xiao, C Jiang, S Yue, M Zhang… - Frontiers in cell and …, 2022 - frontiersin.org
… is often ineffective in slowing the progression of the disease. In fact, a … osteosarcoma.
Knockdown of METTL3 inhibited the proliferation, migration and invasion of human osteosarcoma

The prognostic value and immune landscapes of m¹A/m5C/m6A-associated lncRNA signature in osteosarcoma.

ZY Wu, ZY Shi - European Review for Medical & …, 2022 - search.ebscohost.com
… the prognosis of osteosarcoma patients is urgently needed. … N1-methyladenosine (m1A),
5-methylcytosine (m5C), and N6-… m1A/m5C/m6A in osteosarcoma progression, and the role of …

[HTML][HTML] Refining the role of N6-methyladenosine in cancer

J Koch, F Lyko - Current Opinion in Genetics & Development, 2024 - Elsevier
… N 6 -methyladenosine (m 6 A) is the most abundant internal modification of eukaryotic
mRNAs. m 6 A affects the fate of its targets in all aspects of the mRNA life cycle and has important …

[HTML][HTML] Regulation of N6-methyladenosine in the differentiation of cancer stem cells and their fate

Y Xu, J Liu, WJ Chen, QQ Ye, WT Chen… - Frontiers in Cell and …, 2020 - frontiersin.org
N6-methyladenosine (m6A) is one of the most common … is also involved in tumor progression
and stem cell differentiation… Although osteosarcoma is potentially initiated from a single cell …