Third-generation sequencing in the clinical laboratory: exploring the advantages and challenges of nanopore sequencing

LM Petersen, IW Martin, WE Moschetti… - Journal of clinical …, 2019 - Am Soc Microbiol
… innovation of nanopore sequencing from Oxford Nanoporesequencing is an attractive
platform for clinical laboratories to … detection in clinical specimens by metagenomic sequencing, …

Nanopore sequencing in a clinical routine laboratory: challenges and opportunities.

J Schmidt, F Blessing, L Fimpler… - … Laboratory, 2020 - search.ebscohost.com
… So far, Nanopore sequencing is not used in clinical laboratories to investigate routine … are
numerous published clinical research applications which show the flexibility of nanopore se…

Oxford nanopore sequencing in clinical microbiology and infection diagnostics

D Sheka, N Alabi, PMK Gordon - Briefings in bioinformatics, 2021 - academic.oup.com
nanopore sequencing for clinical microbiological use. The ONT Flongle is a novel TGS
sequencing … The clinical laboratory suitability of Flongle is also supported by its track record of …

Clinical performance of nanopore targeted sequencing for diagnosing infectious diseases

Y Fu, Q Chen, M Xiong, J Zhao, S Shen… - Microbiology …, 2022 - Am Soc Microbiol
… All samples were collected in sterile tubes and sent to the clinical laboratory for DNA
extraction. Specific pretreatment procedures were performed according to different sample types. …

Nanopore sequencing and its clinical applications

X Sun, L Song, W Yang, L Zhang, M Liu, X Li, G Tian… - Precision Medicine, 2020 - Springer
… Recently, the nanopore sequencing technology is widely … nanopore sequencing instrument
from Oxford Nanoporesequencing, long sequencing reading, fast sequencing speed, …

Comparison of illumina and Oxford nanopore sequencing technologies for pathogen detection from clinical matrices using molecular inversion probes

CP Stefan, AT Hall, AS Graham, TD Minogue - The Journal of Molecular …, 2022 - Elsevier
… We describe the ability of Illumina and Oxford Nanopore Technologies (ONT) to sequence
sequencing platforms detected 18 viral and parasitic organisms directly from mock clinical

[HTML][HTML] A novel approach to detect IDH point mutations in gliomas using nanopore sequencing: test validation for the clinical laboratory

ML Mimosa, W Al-Ameri, JT Simpson, M Nakhla… - The Journal of Molecular …, 2023 - Elsevier
clinical laboratories. We hypothesized that third-generation nanopore sequencing by Oxford
Nanopore … and validate a nanopore-based IDH mutation detection assay for clinical practice …

Assessing nanopore sequencing for clinical diagnostics: a comparison of next-generation sequencing (NGS) methods for Mycobacterium tuberculosis

C Smith, TA Halse, J Shea, H Modestil… - Journal of clinical …, 2020 - Am Soc Microbiol
nanopore sequencing can be a suitable alternative to, or complement, currently used
sequencing platforms in a clinical … widely adopted in public health laboratories in the near future. …

Challenges in the application of NGS in the clinical laboratory

Y Yin, C Butler, Q Zhang - Human immunology, 2021 - Elsevier
… The Oxford Nanopore uses a protein pore inserted into a … nucleic acids pass through
biological nanopores [69]. The … the Nanopore, with the current record of Nanopore sequencing

Nanopore sequencing: from imagination to reality

H Bayley - Clinical chemistry, 2015 - academic.oup.com
… The nanopore platform that has been developed is also … ), the possibility of nanopore
sequencing was not on our agenda… Our ideas included the incorporation of nanopores into filters …