Application of Nanopore sequencing in the diagnosis and treatment of pulmonary infections

J Chen, F Xu - Molecular Diagnosis & Therapy, 2023 - Springer
sequencing), tuberculosis, and atypical pathogens. Furthermore, we discuss the role of
nanopore sequencing in … , emphasizing its advantages in sequencing genome repeat areas and …

Potential utility of targeted Nanopore sequencing for improving etiologic diagnosis of bacterial and fungal respiratory infection

WS Chan, CH Au, SM Leung, DN Ho, EYL Wong… - Diagnostic …, 2020 - Springer
… In this study, we explored the use of Nanopore sequencing … We developed a targeted
Nanopore method for simultaneous … routine infectious disease workups on archived respiratory

Nanopore-based metagenomic sequencing in respiratory tract infection: a developing diagnostic platform

R Chapman, L Jones, A D'Angelo, A Suliman, M Anwar… - Lung, 2023 - Springer
Respiratory tract infection (RTI) remains a significant cause … identification via evaluation of
respiratory samples, a process which … Nanopore sequencing (NPS) of respiratory samples has …

Clinical application of nanopore-targeted sequencing technology in bronchoalveolar lavage fluid from patients with pulmonary infections

J Ye, K Huang, Y Xu, N Chen, Y Tu, J Huang… - Microbiology …, 2024 - Am Soc Microbiol
… This study holds paramount significance in advancing the field of respiratory infection … with
pulmonary infections, we illuminate the promising potential of nanopore-targeted sequencing (…

Identifying bacterial airways infection in stable severe asthma using Oxford nanopore sequencing technologies

MF Jabeen, ND Sanderson, D Foster… - Microbiology …, 2022 - Am Soc Microbiol
… a method for Oxford Nanopore sequencing for the unbiased … performance of Illumina MiSeq,
Nanopore sequencing, and RT-… of pulmonary infection for metagenomic sequencing using …

Clinical performance of nanopore targeted sequencing for diagnosing infectious diseases

Y Fu, Q Chen, M Xiong, J Zhao, S Shen… - Microbiology …, 2022 - Am Soc Microbiol
nanopore sequencing platform to sequence the amplified products, has been developed
for the diagnosis of bacterial or fungal infection … with lower respiratory tract infections (137/307, …

The application of nanopore targeted sequencing for pathogen diagnosis in bronchoalveolar lavage fluid of patients with pneumonia: a prospective multicenter study

Q Lin, Y Yao, X Li, S Zhang, H Guo, X Ma… - Infectious …, 2024 - Taylor & Francis
… of pulmonary infection, 246 strains of pathogens were confirmed. Nanopore targeted
sequencing … Metagenomic next-generation sequencing had a sensitivity of 82.9%. Total of 70.1% …

Nanopore metagenomics enables rapid clinical diagnosis of bacterial lower respiratory infection

T Charalampous, GL Kay, H Richardson, A Aydin… - Nature …, 2019 - nature.com
… We present an optimized nanopore sequencing-based clinical metagenomics framework
for bacterial LRIs that removes up to 99.99% of host nucleic acid from clinical respiratory

The application of targeted nanopore sequencing for the identification of pathogens and resistance genes in lower respiratory tract infections

H Zhang, M Wang, X Han, T Wang, Y Lei… - Frontiers in …, 2022 - frontiersin.org
… based on nanopore sequencing for the identification of bacterial and fungal infections of clinical
… , identified via TNPseq, conformed to the epidemiology of respiratory infections in China. …

A dual-process of targeted and unbiased Nanopore sequencing enables accurate and rapid diagnosis of lower respiratory infections

Y Guo, Z Li, L Li, S Li, L Sun, X Yang, Y Dai, J Gu… - …, 2023 - thelancet.com
… This study illustrated the diagnostic performance of LRTIs with Nanopore sequencing in
real clinical settings. We developed a NanoMP approach with dual barcodes and performed …