… in nasal vaccine delivery will be described along with future prospects. A brief introduction
to the anatomy and physiology of the nasal cavity … for the nasal route will also be discussed. …

… nasal delivery of two previously characterized broadly neutralizing antibodies (F61 and
H121) protected K18-hACE2 mice against lethal challenge … evaluated by lethal challenge with …

… Twenty-eight days after vaccination, animals were challenged with 200 LD 50 … nasal route
survived the lethal challenge (Figure 5A). This was evident as early as 5 days after challenge …

… delivery route rather than the choice of adjuvant. The presence of a nasal IgA response
following IN delivery … the IN SFD rPA delivery group displayed a weak nasal IgA response (titer = …

… Furthermore, nasal delivery of siRNA by chitosan nanoparticle complex has antiviral effects
and significantly protected BALB/c mice from a lethal influenza challenge. These findings …

… delivery systems, virus-like particles, vaccine manufacture, challenges of regulatory authorities,
and the nasal vaccine … of the flu viruses (eg swine flu) to become more virulent and lethal. …

… survival rate) against multiple lethal challenge doses of mouse-… against a lethal viral challenge
with 1–5 lethal dose 50 (LD 50 … at developing a nasal spray capable of delivering effective …

… The efficiency of the chitosan–pcDNA3–VP1 complexes was also proven after lethal CVB3
challenge, where 43% of the mice were protected and demonstrated a significant reduction of …

… protected against the challenge lethal PR8 Citation[112]. Apart from micro-/nano-carrier
vaccine system described above, a small number of nasal vaccine delivery systems using other …

… lethal challenge [63]. It is of note that the protection study involved three immunizations prior
to challenge… humoral responses and protection against challenge. The co-administration of …