Nasal vaccination against SARS-CoV-2: Synergistic or alternative to intramuscular vaccines?

M Tiboni, L Casettari, L Illum - International journal of pharmaceutics, 2021 - Elsevier
… It is striking that all marketed SARS-CoV-2 vaccines are … –95%) depending on the type of
vaccine. However, little protection is … a risk of transmission of virus from vaccinated individuals. …

Nasal nanovaccines for SARS-CoV-2 to address COVID-19

J Huang, Y Ding, J Yao, M Zhang, Y Zhang, Z Xie… - Vaccines, 2022 - mdpi.com
… ideal SARS-CoV-2 vaccines can stimulate the nasal mucosa to produce systemic immunity
and mucosal immunity. Among them, the nasal … and envelope protein of SARS-CoV-2 can be …

Intranasal vaccines for SARS-CoV-2: From challenges to potential in COVID-19 management

VP Chavda, LK Vora, AK Pandya, VB Patravale - Drug discovery today, 2021 - Elsevier
… In this review, we provide an overview of nasal vaccines with a focus on formulation
development as well as ongoing preclinical and clinical studies for SARS-CoV-2 intranasal vaccine

COVID-19 vaccines may not prevent nasal SARS-CoV-2 infection and asymptomatic transmission

BS Bleier, M Ramanathan Jr… - … –Head and Neck …, 2021 - journals.sagepub.com
vaccine demonstrated detectable viral RNA in the nasal swabs of several participants after
SARS-CoV… The findings of elevated nasal viral titers despite the effective prevention of COVID-…

A nasal vaccine with inactivated whole-virion elicits protective mucosal immunity against SARS-CoV-2 in mice

N Tokunoh, S Tamiya, M Watanabe… - Frontiers in …, 2023 - frontiersin.org
… Therefore, in this study, we focused on using the inactivated WV as a nasal vaccine against
SARS-CoV-2. We examined the potential of an inactivated WV as an antigen to induce S-…

[HTML][HTML] SARS-CoV-2-specific nasal IgA wanes 9 months after hospitalisation with COVID-19 and is not induced by subsequent vaccination

F Liew, S Talwar, A Cross, BJ Willett, S Scott… - …, 2023 - thelancet.com
… We studied nasal and plasma antibody responses one year … a period when SARS-CoV-2
vaccination was introduced. … in nasal and plasma IgA and IgG anti-S titres for all SARS-CoV-2 …

Oral and intranasal vaccines against SARSCoV‐2: Current progress, prospects, advantages, and challenges

S Kar, P Devnath, TB Emran, TE Tallei… - Immunity …, 2022 - Wiley Online Library
… In this article, the current approaches used to develop effective oral and nasal mucosal
vaccines against SARS-CoV-2 and their benefits, prospects, and challenges have been …

Nasal prevention of SARS-CoV-2 infection by intranasal influenza-based boost vaccination in mouse models

R Zhou, P Wang, YC Wong, H Xu, SY Lau, L Liu… - …, 2022 - thelancet.com
… that an effective vaccine should induce mucosal immunity for nasal protection to prevent
SARS-CoV-2 asymptomatic infection and silent spread. Recently, thousands of vaccine-…

[HTML][HTML] The central role of the nasal microenvironment in the transmission, modulation, and clinical progression of SARS-CoV-2 infection

O Gallo, LG Locatello, A Mazzoni, L Novelli… - Mucosal …, 2021 - Elsevier
vaccination to SARS-CoV, virus-specific Trm cells develop in the lungs, while if the …
accumulation of SARS-CoV-2 specific T cells in the UA thanks to a nasal vaccination may guarantee …

Improvement of mucosal immunity by a live-attenuated SARS-CoV-2 nasal vaccine

J Yeung, T Wang, PY Shi - Current Opinion in Virology, 2023 - Elsevier
nasal vaccines could further reduce SARS-CoV-2 transmission. We discuss the benefits of
intranasal live-attenuated SARS-CoV-2 vaccines, … developing an attenuated vaccine platform. …