Differential integration of transcriptome and proteome identifies pan-cancer prognostic biomarkers

GW Schwartz, J Petrovic, Y Zhou, RB Faryabi - Frontiers in genetics, 2018 - frontiersin.org
… We also simulated the effect of noisy high-throughput experiments on the accuracy of
transcriptomics and proteomics integrative analysis. To simulate this source of network inaccuracy, …

Gene network and proteomic analyses of cardiac responses to pathological and physiological stress

I Drozdov, A Didangelos, X Yin… - Circulation …, 2013 - Am Heart Assoc
… into the integrated molecular mechanisms of pathological versus physiological cardiac
hypertrophy by representing transcriptomic and proteomic data as biological networks. The …

Next-generation proteomics: towards an integrative view of proteome dynamics

AFM Altelaar, J Munoz, AJR Heck - Nature Reviews Genetics, 2013 - nature.com
… different PTMs; this complexity forces us to change our classical view of signalling networks
from a linear information flow into a highly intricate and multidirectional regulatory network. …

Evidence for the presence of disease-perturbed networks in prostate cancer cells by genomic and proteomic analyses: a systems approach to disease

B Lin, JT White, W Lu, T Xie, AG Utleg, X Yan, EC Yi… - Cancer research, 2005 - AACR
… built comprehensive MPSS and proteomic databases. The integrated mRNA and protein …
onto extant physiologic networks, creating perturbation networks that reflect prostate cancer …

Integrated transcriptome and proteome analyses identify novel regulatory network of nucleus pulposus cells in intervertebral disc degeneration

C Xu, S Luo, L Wei, H Wu, W Gu, W Zhou, B Sun… - BMC medical …, 2021 - Springer
… transcriptomic profiling data, we integrated the proteomic and transcriptomic data of … network
to show the combined regulatory network of intervertebral disc degeneration. In the network, …

A transcriptome-proteome integrated network identifies endoplasmic reticulum thiol oxidoreductase (ERp57) as a hub that mediates bone metastasis

N Santana-Codina, R Carretero… - … & Cellular Proteomics, 2013 - ASBMB
… BIANA creates and analyzes biological networks and GUILD prioritizes the biomolecules
in the network according to their relevance to a given phenotype. We enriched the network

Network generation enhances interpretation of proteomic data from induced apoptosis

RF Deighton, LE Kerr, DM Short, M Allerhand… - …, 2010 - Wiley Online Library
… To gain further insight into the integrated cellular response to apoptosis, … network analysis
to the differentially expressed list of proteins identified by our previous quantitative proteomic

Integration of proteomics into systems biology of cancer

S Hanash, M Schliekelman, Q Zhang… - … : Systems Biology and …, 2012 - Wiley Online Library
… the proteome is strictly … proteomic study comparing metastatic and nonmetastatic cell lines
revealed a multilayered transforming growth factor β (TGFβ) regulatory network by integrating

Network analyses and data integration of proteomics and metabolomics from leaves of two contrasting varieties of sugarcane in response to drought

IGF Budzinski, FE de Moraes, TR Cataldi… - Frontiers in plant …, 2019 - frontiersin.org
… for metabolomics and proteomics, respectively. In order to build the network, we needed to
have the same number of biological samples for metabolomics and proteomics. The drought …

Integrated omics dissection of proteome dynamics during cardiac remodeling

E Lau, Q Cao, MPY Lam, J Wang, DCM Ng… - Nature …, 2018 - nature.com
… 6) and also when we cross-referenced the turnover networks with a prior data set on …
The results are robust to network construction parameters, and are reproduced when …