Dissecting the molecular mechanisms of neurodegenerative diseases through network biology

JA Santiago, V Bottero, JA Potashkin - Frontiers in aging …, 2017 - frontiersin.org
… , we highlight the most recent advances in network biology applications to understand
the most common neurodegenerative diseases with an emphasis on brain specific networks. …

Network analysis for complex neurodegenerative diseases

C Manzoni, PA Lewis, R Ferrari - Current Genetic Medicine Reports, 2020 - Springer
… , functional biology, informatics, mathematics and systems biology. This … network analysis)
to interpret large and different datasets in the context of complex neurodegenerative diseases

A network approach to clinical intervention in neurodegenerative diseases

JA Santiago, JA Potashkin - Trends in molecular medicine, 2014 - cell.com
diseases. Here, we summarize the recent advances in network biology to untangle the
molecular … giving rise to the most prevalent neurodegenerative diseases. We propose that …

Systems biology and gene networks in neurodevelopmental and neurodegenerative disorders

NN Parikshak, MJ Gandal, DH Geschwind - Nature Reviews Genetics, 2015 - nature.com
… We discuss new insights into neurodevelopmental disorders and neurodegenerative
diseases from these studies, highlight emerging themes and provide recommendations for …

Systems biology of neurodegenerative diseases

LB Wood, AR Winslow, SD Strasser - Integrative Biology, 2015 - academic.oup.com
… Bayesian networks attempt to identify causal relationships between variables by maximizing
the a posteriori probability that local network interactions exist given a priori network

A systems biology approach for studying neurodegenerative diseases

S Lam, A Bayraktar, C Zhang, H Turkez, J Nielsen… - Drug Discovery …, 2020 - Elsevier
… , traditional neurodegeneration research remains marred by narrow-sense approaches
surrounding amyloid β (Aβ), tau, and α-synuclein (α-syn). A systems biology approach enables …

A comparative system‐level analysis of the neurodegenerative diseases

R Godini, H Fallahi, E Ebrahimie - Journal of cellular physiology, 2019 - Wiley Online Library
… Additionally, by PPI network centrality analysis and applying enrichment maps, we found
about 100 hub genes, including UMPS in AD; KIT and CCR7 in ALS; GAD1, RAC1, GNAO1, …

A computational analysis of protein-protein interaction networks in neurodegenerative diseases

J Goñi, FJ Esteban, NV de Mendizábal, J Sepulcre… - … systems biology, 2008 - Springer
network and thereby, inducing significant side effects. The results we present here indicate
that both neurodegenerative diseases (… in two of the four disease networks, a high degree of …

Deciphering complex mechanisms in neurodegenerative diseases: the advent of systems biology

F Noorbakhsh, CM Overall, C Power - Trends in neurosciences, 2009 - cell.com
biological pathways in which large numbers of structurally and functionally diverse biomolecules
are measured simultaneously over time in cells, networks of cells or whole organisms [ …

Molecular nexopathies: a new paradigm of neurodegenerative disease

JD Warren, JD Rohrer, JM Schott, NC Fox, J Hardy… - Trends in …, 2013 - cell.com
… brain networks is a key issue in neurodegenerative disease. … of network damage. The
paradigm has implications for understanding and predicting neurodegenerative disease biology. …