C Manzoni, PA Lewis, R Ferrari - Current Genetic Medicine Reports, 2020 - Springer
… , functional biology, informatics, mathematics and systems biology. This … network analysis) to interpret large and different datasets in the context of complex neurodegenerativediseases…
JA Santiago, JA Potashkin - Trends in molecular medicine, 2014 - cell.com
… diseases. Here, we summarize the recent advances in networkbiology to untangle the molecular … giving rise to the most prevalent neurodegenerativediseases. We propose that …
… We discuss new insights into neurodevelopmental disorders and neurodegenerative diseases from these studies, highlight emerging themes and provide recommendations for …
… Bayesian networks attempt to identify causal relationships between variables by maximizing the a posteriori probability that local network interactions exist given a priori network …
… , traditional neurodegeneration research remains marred by narrow-sense approaches surrounding amyloid β (Aβ), tau, and α-synuclein (α-syn). A systems biology approach enables …
… Additionally, by PPI network centrality analysis and applying enrichment maps, we found about 100 hub genes, including UMPS in AD; KIT and CCR7 in ALS; GAD1, RAC1, GNAO1, …
… network and thereby, inducing significant side effects. The results we present here indicate that both neurodegenerativediseases (… in two of the four diseasenetworks, a high degree of …
… biological pathways in which large numbers of structurally and functionally diverse biomolecules are measured simultaneously over time in cells, networks of cells or whole organisms [ …
… brain networks is a key issue in neurodegenerativedisease. … of network damage. The paradigm has implications for understanding and predicting neurodegenerativediseasebiology. …