Inflammation and gliosis in neurological diseases–clinical implications

A Członkowska, I Kurkowska-Jastrzębska - Journal of neuroimmunology, 2011 - Elsevier
… During MPTP induced degeneration activated microglia start to express de novo various …
After stroke many pro-inflammatory cytokines expression is elevated in blood and cerebrospinal …

The role of Th17 cells in auto-inflammatory neurological disorders

F Tahmasebinia, A Pourgholaminejad - Progress in Neuro …, 2017 - Elsevier
… polarize in the site of inflammation in presence of pro-inflammatory cytokines. Furthermore,
pro-… can switch on apoptotic pathways in neurons and ultimately lead to neural degeneration. …

Cytokines in CNS disorders: neurotoxicity versus neuroprotection

G Stoll, S Jander, M Schroeter - Advances in Dementia Research, 2000 - Springer
… balanced by upregulation of antiinflammatory cytokines such as IL… in ischemic damage and
neurological deficit was observed … to degeneration of the distal stump referred to as Wallerian …

Macrophages and neurodegeneration

JJA Hendriks, CE Teunissen, HE de Vries… - Brain Research …, 2005 - Elsevier
… of MS lesions, and neurological deficits are often ascribed to … , which may indicate axonal
degeneration distal from the sites … such as pro-inflammatory cytokines, free radicals, glutamate …

Inflammatory mechanisms and oxidative stress as key factors responsible for progression of neurodegeneration: role of brain innate immune system

J Leszek, GE Barreto, K Gasiorowski… - CNS & Neurological …, 2016 - ingentaconnect.com
… or immune pathways are over expressed with age and promote degeneration, or whether …
apoptosis and reduced secretion of proinflammatory cytokines, also revealed lower expression …

Microglia and cytokines in neurological disease, with special reference to AIDS and Alzheimer's disease

DW Dickson, SC Lee, LA Mattiace, SHC Yen… - Glia, 1993 - Wiley Online Library
… antigens and to inflammatory cytokines (interleukin1-p and … can be activated by neuronal
degeneration. These results … participate in a local inflammatory cascade that promotes tissue …

Role of immunity and inflammation in the pathophysiology of neurodegenerative diseases

M Fakhoury - Neurodegenerative Diseases, 2015 - karger.com
… role in neurodegenerative disorders since its … -inflammatory cytokines like TNF-α, TGF-β
and interleukin-6 (IL-6) compared to healthy individuals, suggesting a key role of inflammation

(Peri) vascular production and action of pro-inflammatory cytokines in brain pathology

JP Konsman, B Drukarch, AM Van Dam - Clinical science, 2007 - portlandpress.com
… with intermittent episode of neurological dysfunction [41a]. … into the neuropil accompanied
by degeneration of non-migrating … Although neuronal degeneration is most important in the …

Microglia-neuron interaction in inflammatory and degenerative diseases: role of cholinergic and noradrenergic systems

L Minghetti, D Carnevale… - CNS & Neurological …, 2007 - ingentaconnect.com
… for its inhibitory activities on production of proinflammatory cytokines (IL-12, TNF-α and IFN-)
… anti-inflammatory cytokines such as IL-10 and TGF-. As a result of such a selective cytokine

Inflammatory process as a determinant factor for the degeneration of substantia nigra dopaminergic neurons

AJ Herrera, M Tomas-Camardiel, JL Venero… - Journal of neural …, 2005 - Springer
… We have developed an animal model of dopaminergic neurons degeneration by the
single … of inflammatory process in relationship to the dopaminergic degeneration in the SN. …