[HTML][HTML] Complete mapping of viral escape from neutralizing antibodies

MB Doud, SE Hensley, JD Bloom - PLoS pathogens, 2017 - journals.plos.org
… selection that an antibody exerts on all these mutations in a … identify mutations that affect
antibody neutralization—for … different mutations have the largest effect on antibody escape

[HTML][HTML] Escape from neutralizing antibodies by SARS-CoV-2 spike protein variants

Y Weisblum, F Schmidt, F Zhang, J DaSilva, D Poston… - elife, 2020 - elifesciences.org
… Here, we describe a recombinant chimeric virus approach that can rapidly generate and
evaluate SARS-CoV-2 S mutants that escape antibody neutralization. We show that mutations

In vivo and in vitro escape from neutralizing antibodies 2G12, 2F5, and 4E10

A Manrique, P Rusert, B Joos, M Fischer… - Journal of …, 2007 - Am Soc Microbiol
… Since 2G12 is considered a prototypic antibody to model … in-depth analysis of the 2G12
escape mutants that evolved in our in … of HIV mutants able to escape MPER antibodies exist, we …

Escape from human monoclonal antibody neutralization affects in vitro and in vivo fitness of severe acute respiratory syndrome coronavirus

B Rockx, E Donaldson, M Frieman… - The Journal of …, 2010 - academic.oup.com
neutralizing antibodies in the S1 and S2 domains. We previously characterized a panel of …
neutralization escape mutants and studied the effect of these neutralization escape mutations

Risk of evolutionary escape from neutralizing antibodies targeting SARS-CoV-2 spike protein

D Van Egeren, A Novokhodko, M Stoddard, U Tran… - medRxiv, 2020 - medrxiv.org
… published RBD-targeting neutralizing antibodies (nAbs). Epitopes for RBD-targeting nAbs
overlap one another substantially and can give rise to escape mutants with ACE2 affinities …

Neutralizing antibodies against hepatitis C virus and the emergence of neutralization escape mutant viruses

YK Shimizu, M Hijikata, A Iwamoto, HJ Alter… - Journal of …, 1994 - Am Soc Microbiol
neutralizing antibodies to HCV. Furthermore, we provide the first direct evidence for the
emergence of neutralization escape mutants of … development ofspecific neutralizing antibodies to …

Landscape analysis of escape variants identifies SARS-CoV-2 spike mutations that attenuate monoclonal and serum antibody neutralization

Z Liu, LA VanBlargan, LM Bloyet, PW Rothlauf… - BioRxiv, 2020 - biorxiv.org
… Although neutralizing antibodies against the SARS-CoV-2 … as therapeutics, viral escape
mutants could compromise their efficacy… virus and 19 neutralizing monoclonal antibodies (mAbs) …

Antibody neutralization and escape by HIV-1

X Wei, JM Decker, S Wang, H Hui, JC Kappes, X Wu… - Nature, 2003 - nature.com
Escape virus contained mutations in the env gene that were unexpectedly sparse, did not …
d, de novo neutralizing antibody response to escape variant 212-55. In b–d, subject plasma …

Viral persistence in vivo through selection of neutralizing antibody-escape variants

A Ciurea, P Klenerman, L Hunziker… - Proceedings of the …, 2000 - National Acad Sciences
… oligoclonal primary antibody response (19). In our study, nAb-escape mutants failed to induce
… Quite similar neutralization escape mutants have been described recently in experimental …

[HTML][HTML] Neutralizing antibody therapeutics for COVID-19

AC Hurt, AK Wheatley - Viruses, 2021 - mdpi.com
… Nonetheless, this study highlights mutations that, if present in circulating strains, could
escape either casirivimab, imdevimab or etesevimab and will likely be an important resource for …