Anti-respiratory syncytial virus (RSV) neutralizing antibody decreases lung inflammation, airway obstruction, and airway hyperresponsiveness in a murine RSV model

A Mejías, S Chávez-Bueno, AM Ríos… - Antimicrobial agents …, 2004 - Am Soc Microbiol
… murine model of RSV infection to analyze lung inflammatory abnormalities during both the
acute and … by use of an anti-RSV neutralizing antibody will result in modulation of the immune …

[HTML][HTML] … with a combination of two potent neutralizing antibodies improves clinical outcomes and reduces virus replication and lung inflammation in SARS-CoV-2 …

KKA Van Rompay, KJ Olstad, RL Sammak… - PLoS …, 2021 - journals.plos.org
Neutralizing monoclonal antibodies have shown promise in … a combination of two potent
monoclonal antibodies, C135-LS … -LS antibody combination, or a control monoclonal antibody. …

[HTML][HTML] Enhanced inflammation in New Zealand white rabbits when MERS-CoV reinfection occurs in the absence of neutralizing antibody

KV Houser, AJ Broadbent, L Gretebeck, L Vogel… - PLoS …, 2017 - journals.plos.org
… New Zealand white rabbits display an increase in lung inflammation following reinfection …
-neutralizing antibodies and complement proteins. The development of neutralizing antibodies

[HTML][HTML] An ADAM17-neutralizing antibody reduces inflammation and mortality while increasing viral burden in a COVID-19 mouse model

JF Hedges, DT Snyder, A Robison… - Frontiers in …, 2022 - frontiersin.org
inflammatory cascade is ultimately the reason for the adverse outcomes in COVID-19 and
many other lung inflammatory … In addition to quantifying virus in the lungs, we also performed …

Anti‐HMGB1 neutralizing antibody ameliorates neutrophilic airway inflammation by suppressing dendritic cell‐mediated Th17 polarization

F Zhang, G Huang, B Hu, LP Fang… - … of inflammation, 2014 - Wiley Online Library
… HMGB1 drives the DC-polarized Th17-type response in allergic lung inflammation and that
blocking HMGB1 may benefit the attenuation of neutrophilic airway inflammation in asthma. …

Neutralizing antibodies elicited by a novel detoxified pneumolysin derivative, PlyD1, provide protection against both pneumococcal infection and lung injury

D Salha, J Szeto, L Myers, C Claus… - Infection and …, 2012 - Am Soc Microbiol
… These results indicate that the induction of neutralizing antibodies against PLY can … lung
lesions and inflammation. Our detoxified PlyD1 antigen elicits such PLY neutralizing antibodies, …

Human metapneumovirus persists in BALB/c mice despite the presence of neutralizing antibodies

R Alvarez, KS Harrod, WJ Shieh, S Zaki… - Journal of …, 2004 - Am Soc Microbiol
inflammation. HMPV-specific antibodies were detected by day 14 pi, neutralizing antibody
10 PFU/g of lung tissue) of HMPV/NL/17/00, with neutralizing antibody titers ranging from 3 to …

CXCL6 antibody neutralization prevents lung inflammation and fibrosis in mice in the bleomycin model

AG Besnard, S Struyf, R Guabiraba… - Journal of leukocyte …, 2013 - academic.oup.com
… After demonstrating a significant effect of CXCL6 neutralization, 24 h after … inflammatory
and fibrotic responses was analyzed over a longer time period by repeated neutralizing antibody

TGF-β-neutralizing antibodies improve pulmonary alveologenesis and vasculogenesis in the injured newborn lung

H Nakanishi, T Sugiura, JB Streisand… - … of Physiology-Lung …, 2007 - journals.physiology.org
neutralizing antibodies does not cause inflammation in adult mice (49). Moreover, in the
lungs of the anti-TGF-β antibody-treated mouse pups reported herein, no important inflammation

Neutralizing granulocyte/macrophage colony–stimulating factor inhibits cigarette smoke–induced lung inflammation

R Vlahos, S Bozinovski, SPJ Chan… - American journal of …, 2010 - atsjournals.org
… Previously, GM-CSF has been considered a homeostatic mediator in lung macrophages, …
that antibody neutralization of GM-CSF markedly reduces smoke-induced lung inflammation