Escape from neutralizing antibodies by SARS-CoV-2 spike protein variants

Y Weisblum, F Schmidt, F Zhang, J DaSilva, D Poston… - elife, 2020 - elifesciences.org
… -SARS-CoV-2 agents. However, the degree to which SARS-CoV-2 will adapt to evade
neutralizing antibodies … chimeric VSV/SARS-CoV-2 reporter virus, we show that functional SARS-…

[HTML][HTML] Neutralizing antibodies targeting SARS-CoV-2 spike protein

S Xiaojie, L Yu, Y Guang, Q Min - Stem cell research, 2021 - Elsevier
… In contrast to the antibodies from convalescent patient, in our lab, three potent SARS-CoV-2
neutralizing antibodies were screened from a combinatorial naïve library established 20 …

SARS-CoV-2 spike protein: a key target for eliciting persistent neutralizing antibodies

Y Yang, L Du - Signal transduction and targeted therapy, 2021 - nature.com
… of antibody production and the correlation between IgG antibody titers and neutralizing antibody
titers… 1 This study provides information about the kinetics of antibody production, and the …

[HTML][HTML] Human neutralizing antibodies elicited by SARS-CoV-2 infection

B Ju, Q Zhang, J Ge, R Wang, J Sun, X Ge, J Yu… - Nature, 2020 - nature.com
… infected with SARS-CoV-2. We identified antibodies that potently neutralize SARS-CoV-2;
this … contribute to the observed cross-reactivity with SARS-CoV and MERS-CoV spike protein. …

Receptor-binding domain of SARS-CoV spike protein induces highly potent neutralizing antibodies: implication for developing subunit vaccine

Y He, Y Zhou, S Liu, Z Kou, W Li, M Farzan… - … and biophysical research …, 2004 - Elsevier
virus expressing SARS-CoV S protein resulted in production of neutralizing antibodies (mean
neutralizing … that the S protein can induce protective neutralizing antibodies, although the …

Potent neutralizing antibodies against multiple epitopes on SARS-CoV-2 spike

L Liu, P Wang, MS Nair, J Yu, M Rapp, Q Wang, Y Luo… - Nature, 2020 - nature.com
coronavirus. Here we report the isolation of sixty-one SARS-CoV-2-neutralizing monoclonal
antibodies … The primary target for such antibodies is the viral spike, a trimeric protein 3,4 that …

Spike protein binding prediction with neutralizing antibodies of SARS-CoV-2

T Park, SY Lee, S Kim, MJ Kim, HG Kim, S Jun, SI Kim… - BioRxiv, 2020 - biorxiv.org
… , which binds to viral capsid in a manner that inhibits cellular entry of virus and uncoating of
the … to identify neutralizing antibodies that can bind to SARS-CoV-2 Sipke (S) protein and …

Purified coronavirus spike protein nanoparticles induce coronavirus neutralizing antibodies in mice

CM Coleman, YV Liu, H Mu, JK Taylor, M Massare… - Vaccine, 2014 - Elsevier
… method for development of protein nanoparticles carrying the spike proteins from SARS-CoV
and MERS-CoV that were able to induce significant neutralizing antibody responses in mice…

A therapeutic neutralizing antibody targeting receptor binding domain of SARS-CoV-2 spike protein

C Kim, DK Ryu, J Lee, YI Kim, JM Seo, YG Kim… - Nature …, 2021 - nature.com
… therapeutic benefit of neutralizing antibody CT-P59 targeting RBD of SARS-CoV-2 in vitro
and in vivo studies. We found that CT-P59 binds to RBD of S protein, rendering complete steric …

[HTML][HTML] Longitudinally profiling neutralizing antibody response to SARS coronavirus with pseudotypes

NJ Temperton, PK Chan, G Simmons… - Emerging infectious …, 2005 - ncbi.nlm.nih.gov
SARS-CoV spike protein pseudotypes are the basis of an in … sensitive and specific for
SARS-CoV neutralizing antibodies. … for neutralizing antibodies to the SARS-CoV S protein by …