Neutralizing antibodies to therapeutic enzymes: considerations for testing, prevention and treatment

J Wang, J Lozier, G Johnson, S Kirshner… - Nature …, 2008 - nature.com
… severe adverse clinical effects by neutralizing product activity… for neutralizing antibodies
to abrogate therapeutic effects is … upon development of neutralizing antibodies, eventually …

Neutralizing antibody therapeutics for COVID-19

AC Hurt, AK Wheatley - Viruses, 2021 - mdpi.com
… burden, leading to an urgent need for effective therapeutic strategies. In this article, we
review the role of SARS-CoV-2 neutralizing antibodies (nAbs) in the clinical management of …

Recent advances in therapeutic applications of neutralizing antibodies for virus infections: an overview

MG Ali, Z Zhang, Q Gao, M Pan, EG Rowan… - Immunologic …, 2020 - Springer
… Previous trials in mice strain lacking Fcγ receptors with engineered antibody confirmed
the therapeutic effects of antibodies on the expression of Fcγ receptors [101]. Using anti-CHIKV …

Broadly neutralizing antibodies as treatment: effects on virus and immune system

JN Bhiman, RM Lynch - Current HIV/AIDS Reports, 2017 - Springer
… recent advances in the use of broadly neutralizing antibodies (bNAbs) as therapeutics in …
Thus, many variations of bNAbs will be able to be tested for therapeutic effects in the near …

Effectiveness of topically administered neutralizing antibodies in experimental immunotherapy of respiratory syncytial virus infection in cotton rats

GA Prince, VG Hemming, RL Horswood… - Journal of …, 1987 - Am Soc Microbiol
… of parenterally administered respiratory syncytial virus (RSV)neutralizing antibodies in cotton
… of neutralizing antibodies in serum was required to achieve a therapeutic effect compared …

[HTML][HTML] Neutralizing antibodies for the treatment of COVID-19

Z Zhou, X Wang, Y Fu, X Zhang… - Acta Pharmaceutica Sinica …, 2021 - ncbi.nlm.nih.gov
… the neutralizing antibody has played a therapeutic role. Although the plasma antibody
therapy … side effect; 3) the selected antibodies can be constructed into multivalent or multi-specific …

Neutralizing antibodies induced by gene-based hydrodynamic injection have a therapeutic effect in lethal influenza infection

T Yamazaki, M Nagashima, D Ninomiya… - Frontiers in …, 2018 - frontiersin.org
… In summary, HD provides rapid and potent neutralizing antibodies for a therapeutic effect
that neutralizing antibodies induced by gene transfer provide a prophylactic effect against …

Cure of chronic viral infection by neutralizing antibody treatment

M Ejrnaes, MG von Herrath - Autoimmunity reviews, 2007 - Elsevier
Therapeutic effect of IL-10 modulation by antibody treatment. Treatment of pre-diabetic
mice with a combinatorial regimen consisting of human proinsulin II peptide (B24–C36) and a …

Role of neutralizing antibodies in CMV infection: implications for new therapeutic approaches

V Sandonís, E García-Ríos, MJ McConnell… - Trends in …, 2020 - cell.com
… the role of neutralizing antibodies in protecting against … neutralizing antibodies are directed.
Here, we provide a synthesis of recent data regarding the role of neutralizing antibodies in …

Development of therapeutic antibodies for the treatment of diseases

RM Lu, YC Hwang, IJ Liu, CC Lee, HZ Tsai… - Journal of biomedical …, 2020 - Springer
antibody drugs have increasingly fewer adverse effects due to their high specificity. As a
result, therapeutic antibodies … , the generation of neutralizing human antibodies from human B …