Immunogenicity of mAbs in non-human primates during nonclinical safety assessment

PJK Van Meer, M Kooijman, V Brinks… - MAbs, 2013 - Taylor & Francis
… Two mAbs (MAb15 and MAb22) induced clearing and neutralizing antibodies in NHPs, but
neutralizing antibodies only in humans. In NHPs, ADAs were more often directed against the …

The neutralizing antibody, LY-CoV555, protects against SARS-CoV-2 infection in nonhuman primates

BE Jones, PL Brown-Augsburger, KS Corbett… - Science translational …, 2021 - science.org
… Nonetheless, our approach identified a highly potent neutralizing antibody from a patient
sample that had been characterized as having limited antibody response and neutralizing

[HTML][HTML] Protective efficacy of neutralizing monoclonal antibodies in a nonhuman primate model of Ebola hemorrhagic fever

A Marzi, R Yoshida, H Miyamoto, M Ishijima, Y Suzuki… - PloS one, 2012 - journals.plos.org
… To evaluate the protective efficacy in nonhuman primates, we converted ZGP133/16.3 and
… ) was generated as a control antibody. The neutralizing activities of chimeric MAbs ch133 …

Sustained delivery of a broadly neutralizing antibody in nonhuman primates confers long-term protection against simian/human immunodeficiency virus infection

KO Saunders, A Pegu, IS Georgiev, M Zeng… - Journal of …, 2015 - Am Soc Microbiol
… pertinent to the translation of passive neutralizing antibody transfer as a sustained prevention
strategy in humans. To address this question in a nonhuman primate (NHP) model of HIV-…

Antibody neutralization poses a barrier to intravitreal adeno-associated viral vector gene delivery to non-human primates

MA Kotterman, L Yin, JM Strazzeri, JG Flannery… - Gene therapy, 2015 - nature.com
… , is unclear in large animals. Intravitreal AAV administration … antibody levels on intravitreal
gene delivery, we quantified the anti-AAV antibodies present in sera from non-human primates

LY-CoV555, a rapidly isolated potent neutralizing antibody, provides protection in a non-human primate model of SARS-CoV-2 infection

BE Jones, PL Brown-Augsburger, KS Corbett… - BioRxiv, 2020 - biorxiv.org
neutralizing antibody, LY-CoV555, derived from a convalescent COVID-19 patient. LY-CoV555
was found to have RBD binding and ACE2 blocking … that neutralizing antibodies have …

[HTML][HTML] A DNA vaccine against chikungunya virus is protective in mice and induces neutralizing antibodies in mice and nonhuman primates

K Mallilankaraman, DJ Shedlock, H Bao… - PLoS neglected …, 2011 - journals.plos.org
… in nonhuman primates. We observed that this novel vaccine approach generated protective
levels of immune responses in both mouse and non-human primate … in non-human primates

[PDF][PDF] Vaccine-induced protection from homologous tier 2 SHIV challenge in nonhuman primates depends on serum-neutralizing antibody titers

MG Pauthner, JP Nkolola, C Havenar-Daughton… - Immunity, 2019 - cell.com
… from hard-to-neutralize SHIVBG505 challenge after immunization with native-like BG505
Envelope trimers in nonhuman primates and identify neutralizing antibodies, but not T cell or …

Therapeutic treatment of Nipah virus infection in nonhuman primates with a neutralizing human monoclonal antibody

TW Geisbert, CE Mire, JB Geisbert, YP Chan… - Science translational …, 2014 - science.org
animals show signs of disease. We assessed the efficacy of a fully human monoclonal antibody,
… of clinical illness in a uniformly lethal nonhuman primate model of NiV disease. Sixteen …

Global CNS gene delivery and evasion of anti-AAV-neutralizing antibodies by intrathecal AAV administration in non-human primates

SJ Gray, S Nagabhushan Kalburgi, TJ McCown… - Gene therapy, 2013 - nature.com
… translated from small to large animals. In contrast to studies … or lumbar cistern) in non-human
primates (NHP). Using either … of circulating anti-AAV-neutralizing antibodies up to a 1:128 …