… to SFTSV infection, but the infection in nonhuman primates has not been investigated. This
study … M and immunoglobulin G antibodies, and neutralizing antibodies were identified in all …

… Here we show that MBP134AF, a pan-ebolavirus therapeutic comprising two broadly
neutralizing human antibodies (bNAbs), affords unprecedented effectiveness and potency as a …

… neutralizing antibodies were specific to each vaccine. The regions of GP responsible for
eliciting neutralizing antibodies … at least 80% of neutralization, with increasing concentrations of …

… treated with anti-TNF neutralizing antibody had normal granuloma … of the four animals that
underwent TNF neutralization at the time … Most humanized antibodies can only be delivered to …

… neutralizing antibody response in animals infected with the ECSA strain (DHS-4263) compared
to animals … Paradoxically, the difference in neutralizing capacity observed here was lost …

… had the lowest levels of AAV antibodies). The basis … neutralizing antibody assay, and (3)
the limited scope of the study in terms of animals and their corresponding neutralizing antibody …

… against filovirus infections in preclinical nonhuman primate models are limited. … We tested
one of these neutralizing mAbs that recognized the glycan cap of the GP, designated mAb …

… viral and neutralizing antibodies in this animal species. These … in primates. To test the
possibility that inoculation of the DNA construct can elicit immune responses in nonhuman primates…

… Recent clinical successes of monoclonal antibodies (mAbs… animals experienced 100%
lethality, all animals treated with hu199 at 6 d postinoculation (dpi) survived, and 50% of animals …

… , while retaining the low affinity for activating Fc receptors associated with wild-type IgG4
antibodies. Engagement of activating Fc receptors by a PD-1-blocking antibody could …