βSitosterol attenuates high‐fat diet‐induced intestinal inflammation in mice by inhibiting the binding of lipopolysaccharide to toll‐like receptor 4 in the NFκB pathway

KA Kim, IA Lee, W Gu, SR Hyam… - Molecular nutrition & …, 2014 - Wiley Online Library
… B (NFκB) in the colon was also inhibited by βsitosterol. In LPS‐stimulated intestinal
macrophages, βsitosterol … and inflammatory enzymes as well as NFκB activation. In addition, …

βSitosterol Alleviates Inflammatory Response via Inhibiting the Activation of ERK/p38 and NFκB Pathways in LPS‐Exposed BV2 Cells

Y Sun, L Gao, W Hou, J Wu - BioMed Research International, 2020 - Wiley Online Library
… , β-sitosterol is widely used in the pharmaceutical industry due to its unique biological properties
and physicochemical properties. Studies have shown that β-sitosterol … of β-sitosterol on …

β-sitosterol circumvents obesity induced inflammation and insulin resistance by down-regulating IKKβ/NF-κB and JNK signaling pathway in adipocytes of type 2 …

…, VP Veeraraghavan, CP Palanisamy, B Cui… - Molecules, 2021 - mdpi.com
… IKKβ/NF-κB signaling cascades. SIT treatment dramatically downregulates IKK-β and NF-κB
rats lead to inactivation of IKK-β and inhibition of NF-κB translocation to nucleus all of which …

βSitosterol exhibits anti‐inflammatory activity in human aortic endothelial cells

S Loizou, I Lekakis, GP Chrousos… - Molecular nutrition & …, 2010 - Wiley Online Library
… Results showed that β-sitosterol inhibits significantly … of β-sitosterol and provides new
insights into understanding the molecular mechanism underlying the beneficial effect of β-sitosterol

β-Sitosterol-loaded solid lipid nanoparticles ameliorate complete Freund's adjuvant-induced arthritis in rats: involvement of NF-кB and HO-1/Nrf-2 pathway

F Zhang, Z Liu, X He, Z Li, B Shi, F Cai - Drug delivery, 2020 - Taylor & Francis
… 2 and decreased the expression of NF-κB, RANKL, STAT3. In conclusion, β-sitosterol SLN
showed the antiarthritic effect via suppression of NF-kB and activation of HO-1/Nrf-2 pathway. …

β-sitosterol improves the permeability of lung epithelial cells by inhibiting the NF-kB pathway

X Chen, J Chen, Y Ren, M Wang, Z Yang, W Zhang… - 2023 - researchsquare.com
… The third group is the BS group, which receives β-sitosterol (BS 1 mg/kg intraperitoneally)
at hours 8 and 16 after CLP. All mice will be euthanized at the 24th hour. Lung tissues were …

βSitosterol Alters the Inflammatory Response in CLP Rat Model of Sepsis by Modulation of NFκB Signaling

S Kasirzadeh, MH Ghahremani… - BioMed research …, 2021 - Wiley Online Library
… in the production of other inflammatory factors such as NF-κB, IL-6, and anti-inflammatory …
β-Sitosterol (βS) is a phytosterol found in various plants and has a chemical structure similar …

βSitosterol Protects against Myocardial Ischemia/Reperfusion Injury via Targeting PPARγ/NFκB Signalling

F Lin, L Xu, M Huang, B Deng, W Zhang… - Evidence‐Based …, 2020 - Wiley Online Library
… This study aimed to explore the protective effects of βsitosterol against myocardial I/R …
βSitosterol treatment attenuated H/R‐induced cardiomyocyte injury. Moreover, βsitosterol

βSitosterol Suppresses LPS‐Induced Cytokine Production in Human Umbilical Vein Endothelial Cells via MAPKs and NFκB Signaling Pathway

Y Bi, H Liang, X Han, K Li, W Zhang… - Evidence‐Based …, 2023 - Wiley Online Library
Atherosclerosis (AS) is an inflammatory disease, whose occurrence and development
mechanism is related to a great number of inflammatory cytokines. βsitosterol (BS), a natural …

β-sitosterol alleviates neuropathic pain by affect microglia polarization through inhibiting TLR4/NF-κB signaling pathway

…, Z Zhuang, S Waimei, X Li, Z Chen, B Jing… - Journal of Neuroimmune …, 2023 - Springer
… In cellular experiments, we clearly saw that both β-sitosterol and TLR4/NF-κB signaling pathway
… that β-sitosterol can affect microglial polarization by inhibiting the TLR4/NF-κB signaling …