Targeting the NF-κB pathway in asthma and chronic obstructive pulmonary disease

MR Edwards, NW Bartlett, D Clarke, M Birrell… - Pharmacology & …, 2009 - Elsevier
… importance of NF-κB in asthma and COPD. We will reflect on the various forms of asthma
and … This work demonstrated the importance of NF-κB signalling in both allergic inflammation …

Targeting cell signaling in allergic asthma

SS Athari - Signal transduction and targeted therapy, 2019 - nature.com
… On the other hand, obesity is characterized by a reduced level of adipokine, which functions
as an antiinflammatory and antioxidative mediator attenuating allergic asthma severity. …

NF-kappaB signaling in chronic inflammatory airway disease

M Schuliga - Biomolecules, 2015 - mdpi.com
allergic asthma is the most common asthma … in allergic asthma is characterized by eosinophil
infiltration and activation. Eosinophil contact with airway epithelial cells stimulates NF-κB-…

Inhibition of NF-κB expression and allergen-induced airway inflammation in a mouse allergic asthma model by andrographolide

J Li, L Luo, X Wang, B Liao, G Li - Cellular & Molecular Immunology, 2009 - nature.com
Andrographolide from traditional Chinese herbal medicines previously showed it possesses
a strong anti-inflammatory activity. In present study, we investigated whether …

PI3K/AKT/mTOR and TLR4/MyD88/NF-κB signaling inhibitors attenuate pathological mechanisms of allergic asthma

B Ma, SS Athari, E Mehrabi Nasab, L Zhao - Inflammation, 2021 - Springer
… used to produce allergic asthma models that were … Allergic asthma groups include the
asthma group with no treatment, asthma mice treated with metformin (50mg/kg orally), asthma

Study effect of probiotics and prebiotics on treatment of OVA-LPS-induced of allergic asthma inflammation and pneumonia by regulating the TLR4/NF-kB signaling …

Z Wu, E Mehrabi Nasab, P Arora, SS Athari - Journal of Translational …, 2022 - Springer
… OVA can induce allergic asthma model but, OVA-LPS can induce asthma and acute inflammation
in airways. Also, it can involve with TLR4 and actives TLR4 signaling. Therefore, in this …

Propofol inhibits NF-κB activation to ameliorate airway inflammation in ovalbumin (OVA)-induced allergic asthma mice

Q Zhang, L Wang, B Chen, Q Zhuo, C Bao… - International …, 2017 - Elsevier
… , we aim to investigate the roles of NF-kB activation in propofol anti-asthma effect on OVA-induced
allergic airway inflammation in mice. In a standard experimental asthma model, Balb/c …

Selective blockade of NF-κB activity in airway immune cells inhibits the effector phase of experimental asthma

C Desmet, P Gosset, B Pajak, D Cataldo… - The Journal of …, 2004 - journals.aai.org
… The worldwide prevalence and severity of allergic asthma have increased alarmingly over
the last decades (1). The pathophysiological features of allergic asthma, chronic pulmonary …

Naringenin inhibits allergen-induced airway inflammation and airway responsiveness and inhibits NF-κB activity in a murine model of asthma

Y Shi, J Dai, H Liu, RR Li, PL Sun, Q Du… - Canadian journal of …, 2009 - cdnsciencepub.com
… Therefore, we here evaluated its potential effects in treating acute allergic asthma. … Naringenin
thus exhibited antiinflammatory activity in acute allergic asthma. In patients with asthma, …

Platycodin D attenuates airway inflammation in a mouse model of allergic asthma by regulation NF-κB pathway

T Zhang, S Yang, J Du, Y Jinfu, W Shumin - Inflammation, 2015 - Springer
… Here, using an OVA-induced mouse model of asthma, we show for the first time that PLD
can be effective as a therapeutic drug for the treatment of allergic asthma. Asthma is defined as …