Salvianolic acid A suppress lipopolysaccharide-induced NF-κB signaling pathway by targeting IKKβ

KS Oh, BK Oh, J Mun, HW Seo, BH Lee - International …, 2011 - Elsevier
salvianolic acid A may be potential IKKβ inhibitor, which is critically involved in the suppression
of NF-κB … The objective of the present study was to assess the effect of salvianolic acid A …

Salvianolic acid A attenuates kidney injury and inflammation by inhibiting NF-κB and p38 MAPK signaling pathways in 5/6 nephrectomized rats

H Zhang, Y Wang, C Gao, Y Gu, J Huang… - Acta Pharmacologica …, 2018 - nature.com
Salvianolic acid A (SAA) is a minor phenolic carboxylic acid extracted from Salviae
miltiorrhizae Bunge (Danshen). SAA exhibits a variety of pharmacological activities, such as …

Salvianolic Acid A Protects the Kidney against Oxidative Stress by Activating the Akt/GSK‐3β/Nrf2 Signaling Pathway and Inhibiting the NFκB Signaling Pathway in …

H Zhang, J Wang, Y Wang, C Gao, Y Gu… - Oxidative Medicine …, 2019 - Wiley Online Library
Salvianolic acid A (SAA) is a bioactive polyphenol extracted from Salviae miltiorrhizae … , SAA
significantly lowered the expression of p‐NFκB p65 and ICAM‐1 proteins compared to HK‐…

Salvianolic acid A exhibits anti-inflammatory and antiarthritic effects via inhibiting NF-κB and p38/MAPK pathways

S Feng, H Cong, L Ji - Drug Design, Development and Therapy, 2020 - Taylor & Francis
Salvianolic acid A (SAA) is a type of phenolic acid, derived from a traditional chinese herbal
… to induce OA in vitro and observed whether salvianolic acid A could ameliorate OA. The …

Inhibitory effects of salvianolic acid B on CCl4-induced hepatic fibrosis through regulating NF-κB/IκBα signaling

R Wang, XY Yu, ZY Guo, YJ Wang, Y Wu… - Journal of …, 2012 - Elsevier
… effects of salvianolic acid B on CCl 4 -induced hepatic fibrosis through regulating NF-κB/…
Salvianolic acid B (SA-B) is one of water soluble compounds derived from Salvia miltiorrhiza …

Salvianolic acid B inhibits the TLR4-NFκB-TNFα pathway and attenuates neonatal rat cardiomyocyte injury induced by lipopolysaccharide

J Wang, Y Zhang, L Guo, G Wu, R Liu - Chinese journal of integrative …, 2011 - Springer
… of the TLR4-NFκB-TNFα inflammation pathway on: lipopolysaccharide (LPS)-induced
neonatal rat cardiomyocyte injury and the possible protective effects of salvianolic acid B (Sal B). …

Activation of Nrf2 signaling by salvianolic acid C attenuates NFκB mediated inflammatory response both in vivo and in vitro

J Song, W Zhang, J Wang, H Yang, X Zhao… - International …, 2018 - Elsevier
Neurodegenerative diseases are closely related to neuroinflammation. Drugs targeting
inflammation have been proved to be effective in many animal models. Salvianolic acid C (SalC) …

Salvianolic acid B inhibits atherosclerosis and TNF-α-induced inflammation by regulating NF-κB/NLRP3 signaling pathway

Y Zhao, C Shao, H Zhou, L Yu, Y Bao, Q Mao, J Yang… - Phytomedicine, 2023 - Elsevier
… The aim of this study was to investigate the protective effect of salvianolic acid B (Sal B)
on AS and to explore the molecular mechanism of tumor necrosis factor-α (TNF-α)-induced …

Salvianolic acid A attenuates cell apoptosis, oxidative stress, Akt and NF-κB activation in angiotensin-II induced murine peritoneal macrophages

L Li, T Xu, Y Du, D Pan, W Wu, H Zhu… - Current …, 2016 - ingentaconnect.com
… Abstract: We discuss the role of Salvianolic acid A(SAA), one … , and the expression of Akt and
NF-κB in angiotensin II (Ang II)-… of Akt, p-Akt, NF-κB and p-NF-κB. Ly294002 (the inhibitor of …

Pharmacological effects of salvianolic acid B against oxidative damage

Z Xiao, W Liu, Y Mu, H Zhang, X Wang… - Frontiers in …, 2020 - frontiersin.org
… lipophilic diterpene quinones and hydrophilic phenolic acids, as well as flavonoids, triterpenes,
and sterols. Salvianolic acid B (Sal B) is also named lithospermic acid B. It is one of the …