NF-κB activation

E Abraham - Critical care medicine, 2000 - journals.lww.com
… neutrophils in the lungs of patients with ARDS secondary to NF-κB activation may perpetuate
the pulmonary inflammatory process. Similarly, inhibition of NF-κB activation in patients …

Oxidative stress and redox regulation of lung inflammation in COPD

I Rahman, IM Adcock - European respiratory journal, 2006 - Eur Respiratory Soc
… activates NF-κB-mediated transcription of pro-inflammatory … Enhanced NF-κB-co-activator
complex formation results in … , such as acetylation leading to inflammatory gene expression. …

… stress and TNF-a induce histone Acetylation and NF-кB/AP-1 activation in Alveolar epithelial cells: Potential mechanism In gene transcription in lung inflammation

I Rahman, PS Gilmour, LA Jimenez… - Oxygen/Nitrogen Radicals …, 2002 - Springer
… ease, adult respiratory distress syndrome and idiopathic pul… of immune and inflammatory
cells to the lungs. These cells are … of inflammatory mediators, causing lung inflammation. …

Role of transcription factors in inflammatory lung diseases

I Rahman, W MacNee - Thorax, 1998 - thorax.bmj.com
… linking NF-κB activation to the human lung inflammatory … evaluate the role of NF-κB in lung
inflammation. Intraperitoneal … activation of NF-κB in alveolar macrophages and in lung tissue …

Effects of acteoside on lipopolysaccharide-induced inflammation in acute lung injury via regulation of NF-κB pathway in vivo and in vitro

W Jing, M Chunhua, W Shumin - Toxicology and Applied Pharmacology, 2015 - Elsevier
… Acteoside inhibited NF-кB activation in LPS-induced mice and lung epithelial cells … lung
injury in vivo, we assayed the inflammatory cytokines in LPS stimulated mice. The activation of NF

NADPH oxidase limits lipopolysaccharide-induced lung inflammation and injury in mice through reduction-oxidation regulation of NF-κB activity

W Han, H Li, J Cai, LA Gleaves… - The Journal of …, 2013 - journals.aai.org
… for NF-κB binding activity using the TransAm NF-кB family kit (… NF-κB pathway. Data
presented in this study show that NADPH oxidase limits lung inflammation and injury as well as NF-…

Inhibition of NF-κB-mediated inflammation in severe acute respiratory syndrome coronavirus-infected mice increases survival

ML DeDiego, JL Nieto-Torres, JA Regla-Nava… - Journal of …, 2014 - Am Soc Microbiol
… that lung inflammation … of NF-κB compared to levels for the wild-type virus. Most important,
treatment with drugs that inhibited NF-κB activation led to a reduction in inflammation and lung

Kaempferol regulates MAPKs and NF-κB signaling pathways to attenuate LPS-induced acute lung injury in mice

X Chen, X Yang, T Liu, M Guan, X Feng, W Dong… - International …, 2012 - Elsevier
… the inhibition of tissue oxidative injury and pulmonary inflammatory process. … NF-кB pathways
combined with alleviation of inflammatory reaction and tissue oxidative injury in the lung. …

In vivo antioxidant treatment suppresses nuclear factor-kappa B activation and neutrophilic lung inflammation.

TS Blackwell, TR Blackwell, EP Holden… - … (Baltimore, Md.: 1950 …, 1996 - journals.aai.org
… We studied NF-KB activation in rat lung tissue … NF-KB activation in our model of lung inflammation.
We hypothesized that in vivo endotoxin injection leads to activation of NF-KB in lung

NF-kappaB signaling in chronic inflammatory airway disease

M Schuliga - Biomolecules, 2015 - mdpi.com
… is unequivocally an important component of these diseases, with lung inflammatory cell
profiles varying considerably depending on disease phenotype and which change upon disease …