Role of the NF-kB pathway in the pathogenesis of human disease states

Y Yamamoto, RB Gaynor - Current molecular medicine, 2001 - ingentaconnect.com
… These metabolites contribute to the pathogenesis of the inflammatory process. Finally, NF-κB
is … Thus the NF-κB proteins are important in activating the expression of multiple genes that …

Roles of NF-κB in cancer and inflammatory diseases and their therapeutic approaches

MH Park, JT Hong - Cells, 2016 - mdpi.com
Nuclear factor-κB (NF-κB) is a … processes, including immune response, inflammation, cell
growth and survival, and development. NF-κB is critical for human health, and aberrant NF-κB …

NF-κB signaling in inflammation

T Liu, L Zhang, D Joo, SC Sun - Signal transduction and targeted …, 2017 - nature.com
… Th1 cells are characterized by the secretion of IFN-γ, a cytokine that both promotes cellular
immunity and participate in inflammatory processes. NF-κB promotes Th1 cell differentiation …

NFκB and the link between inflammation and cancer

JA DiDonato, F Mercurio, M Karin - Immunological reviews, 2012 - Wiley Online Library
… : The nuclear factor-κB (NF-κB) transcription factor family has been considered the central
mediator of the inflammatory process … Coincident with the molecular cloning of NF-κB/RelA and …

NF-κB and disease

P Poma - International journal of molecular sciences, 2020 - mdpi.com
… the role of NF-κB in the inflammatory process caused by CCl 4 … pro-inflammatory cytokines
and inhibits apoptosis through NF-… on the role of NF-κB in the inflammatory process, Lyu et al. …

RAGE-dependent NF-kB inflammation processes in the capsule of frozen shoulders

T Yano, Y Hagiwara, A Ando, K Kanazawa… - Journal of Shoulder and …, 2020 - Elsevier
NF-kB promotes the transcription of … inflammation and the progression of atherosclerosis.
RAGE signaling sustains the transcription of NF-kB, leading to prolonged inflammation and …

NF-κB and inflammation in genetic disease

H Sebban, G Courtois - Biochemical pharmacology, 2006 - Elsevier
… itself the expression of numerous mediators of inflammation, NF-κB plays a pivotal role …
inflammation process. Although excessive NF-κB activation is often associated with inflammatory

The complexity of NF-κB signaling in inflammation and cancer

B Hoesel, JA Schmid - Molecular cancer, 2013 - Springer
… true for acute inflammatory processes, where full activation of NF-κB is accompanied by a
high activity of cytotoxic immune cells against cancer cells [77]. On the other hand, NF-κB is …

New regulators of NF-κB in inflammation

S Ghosh, MS Hayden - Nature Reviews Immunology, 2008 - nature.com
… model of nuclear factor-κB (NF-κB) activation, an inflammatory … the activation of the IKK
(inhibitor of NF-κB (IκB) kinase) complex… The broad role of inflammation in pathological processes

NF-κB signaling in the aging process

A Salminen, K Kaarniranta - Journal of clinical immunology, 2009 - Springer
… can suppress the NF-κB-driven inflammatory and aging process (Fig. 1), ie, the entropic … by
inhibiting the NF-κB-driven inflammatory and degenerative processes [3, 69]. NF-κB Signaling…