Physiologically‐based pharmacokinetic modeling‐guided dose Management of Oral Anticoagulants when initiating Nirmatrelvir/ritonavir (Paxlovid) for COVID19 …

Z Wang, ECY Chan - Clinical Pharmacology & Therapeutics, 2022 - Wiley Online Library
… Because nirmatrelvir/ritonavir is prescribed for the treatment of mild to moderate COVID-19,
we postulated that the impact of COVID-19 related cytokine storm on enzymes and …

Early clinical experience with nirmatrelvir/ritonavir for the treatment of COVID19 in solid organ transplant recipients

DM Salerno, DL Jennings, NW Lange… - American Journal of …, 2022 - Wiley Online Library
… but excluded individuals with a history of prior COVID-19 or vaccination. The incidence of …
the nirmatrelvir/ritonavir EUA. This is in line with higher rates of hospitalization for COVID-19 in …

… -world effectiveness of molnupiravir, nirmatrelvir-ritonavir, and sotrovimab on preventing hospital admission among higher-risk patients with COVID-19 in Wales: a …

A Evans, C Qi, JO Adebayo, J Underwood, J Coulson… - Journal of Infection, 2023 - Elsevier
… the effectiveness of sotrovimab, molnupiravir, and nirmatrelvir-ritonavir in preventing hospital
admission and death in higher-risk patients (Fig. 1) with COVID-19 in Wales, UK, during the …

Le nirmatrelvir-ritonavir (Paxlovid®), un traitement contre la Covid-19

J Buxeraud, S Faure, É Fougere - Actualités pharmaceutiques, 2022 - Elsevier
Nirmatrelvir-ritonavir (Paxlovid®), a treatment for Covid-19 The nirmatrelvir-ritonavir (Paxlovid®)
is a treatment against Covid-19 available in pharmacies since February 4, 2022. …

Nirmatrelvir for vaccinated or unvaccinated adult outpatients with Covid-19

J Hammond, RJ Fountaine, C Yunis… - … England Journal of …, 2024 - Mass Medical Soc
… The median time to sustained alleviation of all targeted signs and symptoms of Covid-19
was 12 days in the nirmatrelvirritonavir group and 13 days in the placebo group (P=0.60). Five …

Cardiovascular Drug Interactions With Nirmatrelvir/Ritonavir in Patients With COVID-19: JACC Review Topic of the Week

S Abraham, A Nohria, TG Neilan, A Asnani… - Journal of the American …, 2022 - jacc.org
Nirmatrelvir inhibits a protease enzyme produced by SARS-CoV-2 that is necessary for viral
replication. Low-dose ritonavir is combined with nirmatrelvir as a … Ritonavir is an inhibitor of …

Real-world effectiveness of nirmatrelvir/ritonavir against COVID-19 hospitalizations and severe COVID-19 in community-dwelling elderly Singaporeans during …

LE Wee, AT Tay, C Chiew, BE Young, B Wong… - Clinical Microbiology …, 2023 - Elsevier
… Utilizing a multivariable Cox model with time-updated exposure to nirmatrelvir/ritonavir,
nirmatrelvir/ritonavir was associated with a reduction in the hazard of COVID-19 hospitalization (…

[HTML][HTML] Comparing molnupiravir and nirmatrelvir/ritonavir efficacy and the effects on SARS-CoV-2 transmission in animal models

RM Cox, CM Lieber, JD Wolf, A Karimi… - Nature …, 2023 - nature.com
… In this work, we compare efficacy of molnupiravir and nirmatrelvir/ritonavir in the Roborovski
dwarf hamster model of severe COVID-19-like viral pneumonia and the ferret transmission …

Efficacy of nirmatrelvir and ritonavir for post‐acute COVID19 sequelae beyond 3 months of SARS‐CoV‐2 infection

MH Chuang, JY Wu, TH Liu, WH Hsu… - Journal of Medical …, 2023 - Wiley Online Library
… of nirmatrelvir plus ritonavir (NMV-r) on post-acute COVID-19 … We identified nonhospitalized
adult patients with COVID-19 … and a composite of post-COVID-19 symptoms according to the …

[HTML][HTML] Optimal timing of nirmatrelvir/ritonavir treatment after COVID-19 symptom onset or diagnosis: target trial emulation

CKH Wong, JJ Lau, ICH Au, KTK Lau, IFN Hung… - Nature …, 2023 - nature.com
… of timely COVID-19 treatment using nirmatrelvir/ritonavir … symptom onset, nirmatrelvir/ritonavir
significantly reduced the … investigated whether initiating nirmatrelvir/ritonavir earlier or …