The NLRP3 inflammasome: role and therapeutic potential in pain treatment

H Starobova, EI Nadar, I Vetter - Frontiers in Physiology, 2020 - frontiersin.org
… In summary, our understanding of the therapeutic potential of NLRP3 inhibition for the …
of NLRP3 inhibitors entering clinical trials, significant insights into the therapeutic potential of …

Therapeutic potential of pharmacological targeting NLRP3 inflammasome complex in cancer

G Tezcan, EE Garanina, M Alsaadi… - Frontiers in …, 2021 - frontiersin.org
… Although recent studies demonstrated the potential therapeutic efficacy of VX765, its … of
NLRP3 inflammasome activation and IL-1β and IL-18 secretion. In tumor cell lines where NLRP3

Therapeutic potential of MCC950, a specific inhibitor of NLRP3 inflammasome

H Li, Y Guan, B Liang, P Ding, X Hou, W Wei… - European journal of …, 2022 - Elsevier
… and other inhibitors of NLRP3 inflammasome have also been … We further discuss the
clinical therapeutic potential of … of MCC950 is critical for determining its therapeutic potential. …

Therapeutic potential of the target on NLRP3 inflammasome in multiple sclerosis

S Shao, C Chen, G Shi, Y Zhou, Y Wei, N Fan… - … & therapeutics, 2021 - Elsevier
… The direct involvement of the NLRP3 inflammasome in the occurrence and development of
NLRP3 inflammasome in MS or EAE, as well as inhibitors that specifically target the complex

[HTML][HTML] Evidence and perspective for the role of the NLRP3 inflammasome signaling pathway in ischemic stroke and its therapeutic potential

C Ma, S Liu, S Zhang, T Xu, X Yu… - International …, 2018 - spandidos-publications.com
… evidence for the structure of NLRP3 inflammasome, its activation process in the ischemic
brain and the therapeutic potential of blocking or inhibiting NLRP3 inflammasome signaling. …

Therapeutic potential of targeting the NLRP3 inflammasome in rheumatoid arthritis

J Gao, H Zhang, Y Yang, J Tao - Inflammation, 2023 - Springer
… In this review, we describe the current understanding of NLRP3 activation in RA pathogenesis
… discuss the potential application of specific inhibitors of NLRP3 to provide new therapeutic

[HTML][HTML] Therapeutic potential of MCC950, a specific inhibitor of NLRP3 inflammasome in systemic lupus erythematosus

X Wu, J Yang, J Wu, X Yang - Biomedicine & Pharmacotherapy, 2024 - Elsevier
NLRP3 inflammasome activation pathways in the pathogenesis of SLE and discusses the
potential therapeutic … targeting the NLRP3 pathway in SLE treatment, outlining its potential role …

Inflammasome regulation: therapeutic potential for inflammatory bowel disease

Q Xu, X Zhou, W Strober, L Mao - Molecules, 2021 - mdpi.com
… by elevating the activation of the NLRP3 inflammasome. This suggests that downregulating
the expression of BRCC3 or JOSD2 might be a potential therapeutic strategy for this disease. …

The NLRP3 Inflammasome as a Pathogenic Player Showing Therapeutic Potential in Rheumatoid Arthritis and Its Comorbidities: A Narrative Review

PK Chen, KT Tang, DY Chen - International Journal of Molecular …, 2024 - mdpi.com
… This review focuses on the updated research regarding the NLRP3 inflammasome as a
pathogenic player and its therapeutic potential in RA. We searched the MEDLINE database …

[HTML][HTML] Therapeutic potential of garlic chive-derived vesicle-like nanoparticles in NLRP3 inflammasome-mediated inflammatory diseases

B Liu, X Li, H Yu, X Shi, Y Zhou, S Alvarez… - Theranostics, 2021 - ncbi.nlm.nih.gov
… , suggesting critical involvement of the NLRP3 inflammasome in this disease model. …
therapeutic potential. Therefore, we sought to screen dietary VLNs for anti-NLRP3 inflammasome