Non-randomized evaluation of hospitalization after a prescription for nirmatrelvir/ritonavir versus molnupiravir in high-risk COVID-19 outpatients

K Cowman, A Miller, Y Guo, MH Chang… - Journal of …, 2023 - academic.oup.com
… -risk, non-hospitalized adult COVID-19 patients who received a prescription for molnupiravir
(… Of note, the molnupiravir-treated patients in our study had a higher number of comorbidities …

Hospitalization as an outcome in ambulatory COVID-19 trials—not applicable in every setting

I Núñez, SI Valdés-Ferrer… - Clinical …, 2022 - clinicalmicrobiologyandinfection …
… that treatments for ambulatory patients (remdesivir, molnupiravir, and … molnupiravir). Finally,
the EPIC-HR trial evaluated oral nirmatrelvir among non-hospitalized unvaccinated adults

Efficacy and safety of molnupiravir for the treatment of SARS-CoV-2 infection: a systematic review and meta-analysis

JJ Malin, S Weibel, H Gruell… - Journal of …, 2023 - academic.oup.com
… routine use of molnupiravir for COVID-19 treatment in … -19 who were treated with molnupiravir
[absolute risk reduction (… outpatients with risk factors treated with molnupiravir. Moreover, …

Real-world clinical outcomes of molnupiravir for the treatment of mild to moderate COVID-19 in adult patients during the dominance of the Omicron variant: a meta …

C Huang, TL Lu, L Lin - Antibiotics, 2023 - mdpi.com
… had no benefit for hospitalized patients and showed a decreased mortality risk for non-hospitalized
patients when compared to placebo [32]. This brief meta-analysis included two …

Real-world effectiveness of molnupiravir and nirmatrelvir/ritonavir against mortality, hospitalization, and in-hospital outcomes among community-dwelling, ambulatory …

CKH Wong, ICH Au, KTK Lau, EHY Lau, BJ Cowling… - MedRxiv, 2022 - medrxiv.org
… ) are novel options for treating adult patients with coronavirus … administration of molnupiravir
to non-hospitalized patients … 19 receiving molnupiravir or nirmatrelvir/ritonavir treatment in …

[HTML][HTML] Antiviral drug treatment for nonsevere COVID-19: a systematic review and network meta-analysis

T Pitre, R Van Alstine, G Chick, G Leung, D Mikhail… - Cmaj, 2022 - Can Med Assoc
… antiviral treatments, standard care or placebo in adult patients with … Compared with standard
care or placebo, molnupiravir and … of adding Molnupiravir over standard treatments in mild …

Molnupiravir for the treatment of non-severe COVID-19: a systematic review and meta-analysis of 14 randomized trials with 34 570 patients

M Sun, H Lai, J Huang, J Liu, Y Li, J Tian… - Journal of …, 2023 - academic.oup.com
… We conducted a systematic review and meta-analysis of randomized controlled trials that
allocated adult patients with non-severe COVID-19 to molnupiravir or a control. We used …

Virologic outcomes with molnupiravir in non-hospitalized adult patients with COVID-19 from the randomized, placebo-controlled MOVe-OUT trial

JM Strizki, JA Grobler, N Murgolo, A Fridman… - Infectious Diseases and …, 2023 - Springer
molnupiravir as safe and effective for the treatment of mild-to-moderate COVID-19 in non-hospitalized
adults … the virologic effects of molnupiravir and placebo in this patient population. …

COVID-19 Therapeutics for Nonhospitalized Patients—Updates and Future Directions

KW Chew, PN Malani, RT Gandhi - JAMA, 2023 - jamanetwork.com
Molnupiravir is available through an EUA for treatment of adults 18 years of age and older …
of symptom onset, and for whom alternative treatment options are not available or appropriate. …

Molnupiravir Outpatient Treatment for Adults with COVID-19 in a Real-World Setting—A Single Center Experience

K Czarnecka, P Czarnecka, O Tronina… - Journal of Clinical …, 2022 - mdpi.com
… of non-hospitalized adults with COVID-19, nirmatrelvir/ritonavir and remdesivir are recommended
as the preferred therapies. Molnupiravir is listed as an alternative treatment option only …