Modelling behaviors relevant to brain disorders in the nonhuman primate: Are we there yet?

JT Scott, JA Bourne - Progress in Neurobiology, 2022 - Elsevier
… of activity with nonhuman primates (NHPs) to model human brain disorders. From marmosets
to macaques, the study of NHP species offers a unique window into the function of primate-…

Generation of genetically engineered nonhuman primate models of brain function and neurological disorders

JE Park, AC Silva - American journal of primatology, 2019 - Wiley Online Library
… Research with non-human primates (NHP) has been … of neural circuits in the primate
brain. With the recent … human neurological and neuropsychiatric disorders. In this article…

[HTML][HTML] Non-human Primate Models for Brain Disorders – Towards Genetic Manipulations via Innovative Technology

Z Qiu, X Li - Neuroscience bulletin, 2017 - Springer
… In this review, we discuss key findings using non-human primates to address the neural …
-engineered non-human primate models of autism spectrum disorders and other disorders. …

Nonhuman primate models of neurodegenerative disorders

ME Emborg - ILAR journal, 2017 - academic.oup.com
… Experiments in nonhuman primates (NHPs) account for a small percentage of all research
in animals. Yet the impact of NHP studies for clinical translation is much greater, especially for …

Ethical issues when modelling brain disorders innon-human primates

CP Neuhaus - Journal of Medical Ethics, 2018 - jme.bmj.com
non-human primates (NHPs) well within reach. There is growing interest in creating NHP
models of brain disorders … New treatments are desperately needed for this set of disorders. This …

The dawn of non-human primate models for neurodevelopmental disorders

T Aida, G Feng - Current opinion in genetics & development, 2020 - Elsevier
Non-human primates (NHPs) have been proposed as good models for neurodevelopmental
disorders due to close similarities to humans in terms of brain structure and cognitive …

Opportunities and challenges in modeling human brain disorders in transgenic primates

CG Jennings, R Landman, Y Zhou, J Sharma… - Nature …, 2016 - nature.com
… of new genome engineering technologies such as CRISPR, it is becoming increasingly
feasible to apply these molecular tools in a wider range of species, including nonhuman primates

Contributions of non-human primates to neuroscience research

JP Capitanio, ME Emborg - The Lancet, 2008 - thelancet.com
… which research with non-human primates has played a … disorders. This animal model is
especially valuable because of the many similarities between human and non-human primates

Basal ganglia, movement disorders and deep brain stimulation: advances made through non-human primate research

T Wichmann, H Bergman, MR DeLong - Journal of Neural Transmission, 2018 - Springer
… Studies in non-human primates (NHPs) have led to major advances in our understanding
of … movement disorders such as Parkinson’s disease and hyperkinetic disorders such as …

[HTML][HTML] Non-human primate models of HIV brain infection and cognitive disorders

SJ Byrnes, TA Angelovich, K Busman-Sahay… - Viruses, 2022 - mdpi.com
… accurate non-human primate models. In this review, we describe the major non-human
primate … infection of the brain, and novel therapies targeting brain reservoirs and inflammation. …