[HTML][HTML] Role of structural and non-structural proteins and therapeutic targets of SARS-CoV-2 for COVID-19

R Yadav, JK Chaudhary, N Jain, PK Chaudhary… - Cells, 2021 - mdpi.com
… In this review, we primarily focus on genomic organization, structural and non-structural
protein … plasm therapy, and a myriad of potential vaccines to tackle SARS-CoV-2 infection. …

[HTML][HTML] Role of nonstructural proteins in the pathogenesis of SARSCoV‐2

SJR da Silva, CTA da Silva, RPG Mendes… - Journal of medical …, 2020 - ncbi.nlm.nih.gov
… infection results in higher mortality rates compared to SARSCoV‐2, … SARSCoV‐2. The
ORF1a/b comprise about two‐thirds of the viral genome and codes for 16 nonstructural proteins (…

Structure of nonstructural protein 1 from SARS-CoV-2

LK Clark, TJ Green, CM Petit - Journal of Virology, 2021 - Am Soc Microbiol
… severe acute respiratory syndrome (SARS) appeared in the … novel coronavirus named
SARS coronavirus (SARS-CoV) (1… In 2012, a novel coronavirus named Middle East respiratory …

Structural and functional insights into non-structural proteins of coronaviruses

MA Rohaim, RF El Naggar, E Clayton, M Munir - Microbial pathogenesis, 2021 - Elsevier
… genome may be linked to the unique features of the CoV replication transcription complex
(RTC), which contains many RNA processing enzymes such as the non-structural protein 14's (…

A biochemical perspective of the nonstructural proteins (NSPs) and the spike protein of SARS CoV-2

FK Yoshimoto - The protein journal, 2021 - Springer
… However, this return is threatened by the recent emergence of new SARS CoV-2 strains that
… of the various nonstructural proteins (NSPs) and the spike protein found in SARS CoV-2 to …

Structural characterization of nonstructural protein 1 from SARS-CoV-2

C Semper, N Watanabe, A Savchenko - IScience, 2021 - cell.com
… from SARS-CoV and … SARS-CoV-2, we propose a model of the full-length protein. Our results
provide insight into the molecular structure of a major pathogenic determinant of SARS-CoV

[HTML][HTML] Antibody landscape against SARS-CoV-2 reveals significant differences between non-structural/accessory and structural proteins

Y Li, Z Xu, Q Lei, D Lai, H Hou, H Jiang, Y Zheng… - Cell reports, 2021 - cell.com
… The global antibody responses to non-structural proteins and accessory proteins revealed
in this study will facilitate the comprehensive understanding of SARS-CoV-2 humoral immunity…

Crystal structure of the SARS-CoV-2 non-structural protein 9, Nsp9

DR Littler, BS Gully, RN Colson, J Rossjohn - Iscience, 2020 - cell.com
… The viral proteinsSARS-CoV-2 polyproteins and are released by the action of two internally
encoded proteases. The mature proteins thus released are known as non-structural proteins

Structural and non-structural proteins in SARS-CoV-2: potential aspects to COVID-19 treatment or prevention of progression of related diseases

S Kakavandi, I Zare, M VaezJalali, M Dadashi… - Cell Communication and …, 2023 - Springer
… This review examines the potential role of these SARS-CoV-2 proteins in the initiation of
chronic diseases, and it is anticipated that these proteins could serve as components of an …

Structure and function of major SARS-CoV-2 and SARS-CoV proteins

R Gorkhali, P Koirala, S Rijal… - … and biology insights, 2021 - journals.sagepub.com
SARS-CoV-2 virus, the causative agent of COVID-19 pandemic, has a genomic organization
consisting of 16 nonstructural proteins (nsps), 4 structural proteins, and 9 accessory …