NLRP3 inflammasome activation by Foot-and-mouth disease virus infection mainly induced by viral RNA and non-structural protein 2B

X Zhi, Y Zhang, S Sun, Z Zhang, H Dong, X Luo… - RNA biology, 2020 - Taylor & Francis
… NLRP3 inflammasome plays a protective role against FMDV … activate p-NF-κB/p65 pathway
and viroporin 2B protein can induce ion efflux and trigger NLRP3 inflammasome activation. …

SARS-CoV-2 nonstructural proteins 1 and 13 suppress caspase-1 and the NLRP3 inflammasome activation

NE Kim, DK Kim, YJ Song - Microorganisms, 2021 - mdpi.com
… to counteract inflammasome activity have not been determined. This study, therefore,
attempted to identify SARS-CoV-2 proteins interfering with inflammasome activation using a …

Dengue virus serotype 2 and its non-structural proteins 2A and 2B activate NLRP3 inflammasome

G Shrivastava, G Visoso-Carvajal… - Frontiers in …, 2020 - frontiersin.org
activates the NLRP3 inflammasome is unknown. In this study, we investigated the activation
of the NLRP3 inflammasome … NS2B protein expression increase the NLRP3 inflammasome

Flaviviridae Nonstructural Proteins: The Role in Molecular Mechanisms of Triggering Inflammation

A Latanova, E Starodubova, V Karpov - Viruses, 2022 - mdpi.com
… Among DENV nonstructural proteins, NS2A and NS2B are demonstrated to increase NLRP3
inflammasome activation in endothelial cells, by acting as putative viroporins [329] (Table 6)…

Nonstructural protein NSs activates inflammasome and pyroptosis through interaction with NLRP3 in human microglial cells infected with severe fever with …

C Gao, Y Yu, C Wen, Z Li, H Ding, X Qi… - Journal of …, 2022 - Am Soc Microbiol
activation of the NLRP3 inflammasome may support SFTSV replication in microglial cells.
Viral nonstructural protein … with NLRP3 for the inflammasome activation. It appeared that the N-…

Molecular mechanisms regulating NLRP3 inflammasome activation

EK Jo, JK Kim, DM Shin, C Sasakawa - Cellular & molecular …, 2016 - nature.com
… 71 (non-structural 2B protein), 44 rhinovirus (2B proteins), 45 human respiratory syncytial …
(small hydrophobic protein), 46 are sufficient to stimulate NLRP inflammasome activation. …

The inflammasome pathway is activated by dengue virus non-structural protein 1 and is protective during dengue virus infection

MP Wong, EYW Juan, F Pahmeier, SS Chelluri… - PLoS …, 2024 - journals.plos.org
… induced inflammasome activation is independent of the NLRP3, Pyrin, and AIM2 inflammasome
… We find that DENV NS1-induced inflammasome activation is independent of the NLRP3 …

SARS-CoV-2 non-structural protein 6 triggers NLRP3-dependent pyroptosis by targeting ATP6AP1

X Sun, Y Liu, Z Huang, W Xu, W Hu, L Yi, Z Liu… - Cell Death & …, 2022 - nature.com
… In this study, we found that NLRP3 inflammasome activation caused by autophagic flux
stagnation manifested as concomitant accumulation of LC3B-II and SQSTM1/p62 plays a key …

Coronaviruses: innate immunity, inflammasome activation, inflammatory cell death, and cytokines

SJ Lee, R Channappanavar, TD Kanneganti - Trends in immunology, 2020 - cell.com
… In this review, we focus on our present understanding of innate immune responses,
inflammasome activation, inflammatory cell death pathways, and cytokine secretion during SARS-…

The NLRP3 inflammasome is released as a particulate danger signal that amplifies the inflammatory response

A Baroja-Mazo, F Martín-Sánchez, AI Gomez… - Nature …, 2014 - nature.com
… Assembly of the NLRP3 inflammasome activates caspase-1 and … activation of caspase-1,
oligomeric NLRP3 inflammasomeunstructured parts of the cytoplasm or, in some cells, in the …