… occurs irrespective of the amount of coactivator levels in the cell. In the … also AP-1-targeted
gene repression by glucocorticoids is refractory to increased amounts of nuclear coactivators. …

… variants of the SRC-1 protein. Because CBP represents a common factor, required in addition
to distinct coactivators for function of nuclear receptors, CREB, and AP-1, we suggest that …

… are nuclear proteins that combine with Fos proteins to form a gene-regulatory protein, AP-1. …
activates a distinct and only partially overlapping set of AP-1 target genes"". Using the more …

… in the transcriptional activation of nuclear receptors and AP-1. … conserved coactivators
that increase the specificity of AP-1 … a new group of transcriptional coactivators for AP-1. …

… and/ or acting as adapter molecules between nuclear receptors and the components of the
… nuclear receptors are relatively well defined, along with ASC-1 and ASC-2, two coactivators …

… , and AP-1 component c-Jun, in addition to a series of nuclear … , cotransfected ASC-1
stimulated transactivation mediated by … -1, originally isolated as a coactivator of nuclear receptors (…

… distinct coactivator complexes that mediate nuclear … of coactivator complexes on naturally
occurring nuclear receptor dimers or heterodimers. Although a single LXXLL motif in SRC-1 …

… may regulate nuclear receptor function at … coactivators for nuclear receptors, CREB (cAMP
response element-binding protein) binding protein (CBP), originally identified as a coactivator …

… (a) Western blot analysis of AP-1 components with nuclear protein at different times. Cells …
Equal amount of nuclear protein was loaded. (b) EMSA with nuclear extracts (2 μg) from JB6 P(…

… each other but different from proteins of the SRC-1 family. Almost all of the coactivators will
mediate transcription of many nuclear receptors as well as other transcription regulators. The …