Clinical outcomes following treatment for COVID-19 with nirmatrelvir/ritonavir and molnupiravir among patients living in nursing homes

BHM Ma, TCF Yip, GCY Lui, MSM Lai, E Hui… - JAMA Network …, 2023 - jamanetwork.com
… In contrast, of 14 617 nursing home patients in the current study, 5678 were prescribed with
… and nirmatrelvir/ritonavir for 483 patients. Molnupiravir and nirmatrelvir/ritonavir users had …

[HTML][HTML] Effectiveness of nirmatrelvirritonavir in preventing hospital admissions and deaths in people with COVID-19: a cohort study in a large US health-care system

JA Lewnard, JM McLaughlin, D Malden… - The Lancet Infectious …, 2023 - thelancet.com
… In the USA, oral nirmatrelvirritonavir is authorised for use in patients aged 12 years or older
with … We aimed to establish the effectiveness of nirmatrelvirritonavir in preventing hospital …

Real-world effectiveness of nirmatrelvir/ritonavir against COVID-19 hospitalizations and severe COVID-19 in community-dwelling elderly Singaporeans during …

LE Wee, AT Tay, C Chiew, BE Young, B Wong… - Clinical Microbiology …, 2023 - Elsevier
… Utilizing a multivariable Cox model with time-updated exposure to nirmatrelvir/ritonavir,
nirmatrelvir/ritonavir was associated with a reduction in the hazard of COVID-19 hospitalization (…

[HTML][HTML] Population-based evaluation of the effectiveness of nirmatrelvirritonavir for reducing hospital admissions and mortality from COVID-19

KL Schwartz, J Wang, M Tadrous, BJ Langford… - Cmaj, 2023 - Can Med Assoc
… that nirmatrelvirritonavir was effective in preventing progression to severe COVID-19. Our
objective was to evaluate the effectiveness of nirmatrelvirritonavir … of nirmatrelvirritonavir on …

Nirmatrelvir plus ritonavir for early COVID-19 in a large US health system: a population-based cohort study

S Dryden-Peterson, A Kim, AY Kim… - Annals of internal …, 2023 - acpjournals.org
… some skilled nursing facilities or elder home care programs that … care system encompassing
9 hospitals, hospitalizations outside our system were not included. Positive results on home

Monoclonal antibody and oral antiviral treatment of SARS-CoV-2 infection in US nursing homes

BE McGarry, BD Sommers, AD Wilcock, DC Grabowski… - JAMA, 2023 - jamanetwork.com
… (nirmatrelvir-ritonavir and molnupiravir), as well as new resident COVID-19 weekly cases…
All Medicare-certified nursing homes were required to submit information to NHSN. Facility

Drug interactions with nirmatrelvir-ritonavir in older adults using multiple medications

SB Ross, É Bortolussi-Courval, R Hanula… - JAMA network …, 2022 - jamanetwork.com
… the trial cohort to treatment with nirmatrelvir-ritonavir to identify DDIs with … time of
nirmatrelvir-ritonavir exposure, and/or (2) deprescribing at the approximate time of …

[HTML][HTML] Real-world experience of the comparative effectiveness and safety of molnupiravir and nirmatrelvir/ritonavir in high-risk patients with COVID-19 in a …

Y Mutoh, T Umemura, T Nishikawa, K Kondo, Y Nishina… - Viruses, 2023 - mdpi.com
… Patients receiving long-term care or support were defined as those … care facility, commuting
to the facility, or with nurses visiting their homes routinely to administer medical or living care. …

[HTML][HTML] Nirmatrelvir/ritonavir and molnupiravir in the treatment of mild/moderate COVID-19: results of a real-life study

I Gentile, R Scotto, N Schiano Moriello, B Pinchera… - Vaccines, 2022 - mdpi.com
nirmatrelvir/ritonavir. Three hospitalizations were recorded in the molnupiravir (2.1%) group
and one in the nirmatrelvir/ritonavir (… was 8 days in the nirmatrelvir/ritonavir group vs. 10 days …

What is the place in therapy for nirmatrelvir/ritonavir?

TC Lee, JM Pogue, EK McCreary… - BMJ Evidence-Based …, 2023 - ebm.bmj.com
Nirmatrelvir/ritonavir (Paxlovid, Pfizer) is a combination protease inhibitor that prevents
viral … This analysis summarises what is currently known about nirmatrelvir/ritonavir and the …