… as by the bacterial resistance mechanisms to improve or expand the antimicrobial activity
against target species. Drug treatments operate under two major goals – eradicating bacteria (…

… from an old one is … drug discovery which is typically a “bottom-up” approach based on a
basic science discovery which is later translated into a therapeutic activity through various drug …

… in drug research, evidence of follow-on product introduction was assessed, as were archival
reports of acquisition activity. … , many of which are old, the drugs herein were broadly divided …

… new drugs for the developing world; and (4) potential consequences of recent World Trade
Organization agreements on the availability of old and new drugs. … The trypanocidal activity of …

… NCI’s cancer drug discovery and development activities … Newer drugs are likely to be of
higher quality than older drugs.… drugs tends to be much lower than utilization of old drugs. …

… or,ideally, synergistic antiparasitic activity. In the case of both … new therapies that will retain
activity for a long period. Ideally… , so is lost once resistance develops to either drug. However, …

… -limited drugs whose metabolism declines in old age. Therefore, in vitro studies of activity
and … As yet, there are no data on the effects of age on the expression or activity of any drug …

… of chirality in drug action. Its diastereoisomer, quinine, has virtually no cardiac activity, but …
the importance of continuing to explore older, known drugs for new therapeutic applications. …

… drug, there is a possibility that the original biological activity of the low molecular weight
compound may be lost. … of a polymeric drug which has been discussed even in the older review …

… Specifically, dose-related effects of the drug on activities of daily living and global function …
benefit from the drug, the investigators selected alternative outcomes (activities of daily living …