Numerical analysis of enhanced nano-drug delivery to the olfactory bulb

S Vachhani, C Kleinstreuer - Aerosol Science and Technology, 2021 - Taylor & Francis
… with nanoparticles for targeted drug delivery to the olfactory region. The olfactory deposition
… deposited in the olfactory region Number of particles injected into the nasal cavity (7) …

Effects of intranasal instillation of nanoparticulate matter in the olfactory bulb

SY Kim, KW Kim, SM Lee, S Park, BG Kim, E Choi… - Scientific Reports, 2021 - nature.com
… microscopic findings of olfactory bulbs of control and nano groups. The aggregates of
electron-dense particles (red arrows) were identified in the olfactory bulb of nano group, which was …

Nanoparticles for direct nose-to-brain delivery of drugs

A Mistry, S Stolnik, L Illum - International journal of pharmaceutics, 2009 - Elsevier
… significantly in the olfactory epithelium and in the olfactory bulbs compared to phenylephrine
solutions. These increases in drug levels in the olfactory bulbs were associated with …

Effect of physicochemical properties on intranasal nanoparticle transit into murine olfactory epithelium

A Mistry, SZ Glud, J Kjems, J Randel… - Journal of drug …, 2009 - Taylor & Francis
olfactory neurones and sustentacular cells. Nanoparticles were not found in the olfactory bulbs
… The present study showed no transport of nanoparticles to the olfactory bulbs for any type …

[PDF][PDF] Nano formulation: a novel approach for nose to brain drug delivery

K Singh, Z Ahmad, P Shakya, VA Ansari… - J Chem Pharm …, 2016 - researchgate.net
… to reach the olfactory bulb. The two extracellular transport mediated routes could underlie
the rapid entrance of drug into the brain which can occur within minutes of intranasal drug

Phytochemical-loaded mesoporous silica nanoparticles for nose-to-brain olfactory drug delivery

S Lungare, K Hallam, RKS Badhan - International journal of pharmaceutics, 2016 - Elsevier
… Cellular uptake of nanoparticles into olfactory cells A key goal for our studies was to
demonstrate uptake of MSNP into olfactory bulb neuronal cells. To assess this process fluorescent …

… lipid nanoparticles: Influence of composition, fabrication methods and problems, in vitro drug release and intranasal administration provide to access olfactory bulb …

AK Pawar, LG Hatmode, HR Khandelwal… - GSC Biological and …, 2021 - gsconlinepress.com
drug can be diffused from lipid nanoparticles through diffusion and undergo further passage
through the olfactory bulb … via the olfactory pathway. The additional pathway is a neuronal …

Nanoparticle transport across in vitro olfactory cell monolayers

O Gartziandia, SP Egusquiaguirre, J Bianco… - International journal of …, 2016 - Elsevier
… The olfactory cells, which are located between the supporting cells, start in the olfactory bulb
in the CNS and end at the olfactory epithelium. Therefore, when a drug formulation gets in …

An update on the role of nanovehicles in nose-to-brain drug delivery

Y Feng, H He, F Li, Y Lu, J Qi, W Wu - Drug discovery today, 2018 - Elsevier
… Some nanovehicles are able to deliver nanoparticles (… olfactory nerves, which begin at
the olfactory epithelia and end at the olfactory bulb, form the major direct pathway for NTB drug

Comparison of micron-and nano-particle transport in the human nasal cavity with a focus on the olfactory region

S Vachhani, C Kleinstreuer - Computers in Biology and Medicine, 2021 - Elsevier
… For all parameters considered in this study, the olfactory bulb … In conclusion, the optimal
particle size ranges for olfactory drug … Furthermore, the quantity of drugs delivered to the olfactory