SARS-CoV-2 ORF8: One protein, seemingly one structure, and many functions

S Vinjamuri, L Li, M Bouvier - Frontiers in immunology, 2022 - frontiersin.org
SARS-CoV-2 ORF8 shares a surprisingly low amino acid sequence similarity with SARS-COV
To date, there are numerous unanswered questions about SARS-CoV-2 ORF8 protein

One year of SARS-CoV-2: how much has the virus changed?

S Vilar, DG Isom - Biology, 2021 - mdpi.com
virus is mutating to gauge the likelihood of such an event. Using ≈290,000 SARS-CoV-2
we show that 27 of the proteins comprising the SARS-CoV-2 virus are mutating at different rates…

Human SARS CoV2 spike protein mutations

L Guruprasad - Proteins: Structure, Function, and Bioinformatics, 2021 - Wiley Online Library
… The human spike proteincoronavirus-2 (SARS-CoV-2) protein sequence from Wuhan-Hu-1,
China. Out of 10333 spike protein sequences analyzed, 8155 proteins comprised one or …

Structure and function of major SARS-CoV-2 and SARS-CoV proteins

R Gorkhali, P Koirala, S Rijal… - … and biology insights, 2021 - journals.sagepub.com
… the proteins of SARS-CoV-2 and SARS-CoV are described in great detail. The nsps are
expressed as a single or two … Nsp1 is one of the least mutated proteins during the SARS-CoV-2

[HTML][HTML] Mechanisms of SARS-CoV-2 entry into cells

CB Jackson, M Farzan, B Chen, H Choe - Nature reviews Molecular …, 2022 - nature.com
… the multistep SARS-CoV-2 entry process, including S protein synthesis, S protein structure,
… For SARS-CoV-2, one such trigger is the cleavage of an additional site internal to the …

SARS-CoV-2 one year on: evidence for ongoing viral adaptation

TP Peacock, R Penrice-Randal… - Journal of General …, 2021 - microbiologyresearch.org
… ORF7a is another accessory protein of SARS-CoV-2 and is thought, like its SARS-CoV
orthologue, to interfere with surface expression of host restriction factor tetherin and to modulate …

Structure of SARS-CoV-2 spike protein

J Zhang, T Xiao, Y Cai, B Chen - Current opinion in virology, 2021 - Elsevier
… (d) Additional structures of coronavirus S proteins, including the full-length SARS-CoV-2 S
trimer carrying G614 in the one RBD-up conformation (PDB ID: 7KRR ), the stabilized soluble …

Structural insights into SARS-CoV-2 proteins

R Arya, S Kumari, B Pandey, H Mistry, SC Bihani… - Journal of molecular …, 2021 - Elsevier
SARS-CoV-2, has emerged as one of the most widespread … –function studies of different
SARS-CoV-2 proteins. The efforts … The crystal structure of SARS-CoV-2 main protease (PDB ID: …

[HTML][HTML] A “One-Health” approach for diagnosis and molecular characterization of SARS-CoV-2 in Italy

A Lorusso, P Calistri, MT Mercante, F Monaco… - One Health, 2020 - Elsevier
SARS-CoV-2 strains observed in this study are mainly located in the N protein, there is no
evidence of geographical clustering in the Abruzzo region related to the two N protein viral …

A SARS-CoV-2 protein interaction map reveals targets for drug repurposing

DE Gordon, GM Jang, M Bouhaddou, J Xu, K Obernier… - Nature, 2020 - nature.com
… the molecular details of how SARS-CoV-2 infects cells. Here we … SARS-CoV-2 proteins in
human cells and identified the human proteins that physically associated with each of the SARS