… This review seeks to discuss the influence intestinal and hepatic drug transporters have on
… -life, for orally dosed drugs. This review also describes in detail the Biopharmaceutics Drug …

… of these transporters on the absorption and disposition of a wide range of orally administered
drugs. … of the activity of intestinal transporters to increase the systemic exposure of orally …

… , membrane transporters showed significant impact on the oral absorption of drugs. With
more well established methodology and in-depth understanding, targeting on efflux transporters …

… However, most of the dissolved fraction of orally administered drugs including substrates for
ABC and SLC transporters, except for some weakly basic drugs with higher pKa values, are …

… Intestinal drug transporters Orally administered drugs must pass through the gut wall …
In these cells several drug transporters have been identified, but only a few are known to be …

… transporters is required. In this mini-review, the critical parameters relating to in vivo function
as well as the major intestinal transporter … Since the size of most orally administered drugs …

… role of intestinal microbiota, enterocytes, transporters and various gut-enzymes on the fate
of orally administered drugs. … about a change of the pharmacokinetics of administered drugs. …

… administration and thereby increases patient compliance. However most of the orally administered
drugs … The role of uptake and efflux transporters and their interplay with the metabolic …

… and consequently variability in blood concentrations after oral administration. Intestinal P-glycoprotein
is thought to contribute signiŪcantly to the limited absorption of a range of other …

… transporters that may be targeted to achieve optimal clinical oral plasma exposure for hydrophilic
and polar drugs. … Following oral administration of valcyclovir, acyclovir has a 54% oral …