Emergence of unique SARS-CoV-2 ORF10 variants and their impact on protein structure and function

SS Hassan, K Lundstrom, Á Serrano-Aroca… - International journal of …, 2022 - Elsevier
… Among the 202,968 SARS-CoV-2 ORF10 sequences only 140 … ORF10 sequence found
in the original hCoV-19/Wuhan/WIV04/2019 strain. Furthermore, SARS-CoV-2 ORF10 protein

Notable sequence homology of the ORF10 protein introspects the architecture of SARS-CoV-2

SS Hassan, D Attrish, S Ghosh, PP Choudhury… - International Journal of …, 2021 - Elsevier
… decrease the stability of ORF10 in silico physicochemical and … out on SARS-CoV-2 and
Pangolin-CoV ORF10 proteins, … ORF10 protein similarity of SARS-CoV-2 and Pangolin-CoV, …

SARS-CoV-2 ORF10 impairs cilia by enhancing CUL2ZYG11B activity

L Wang, C Liu, B Yang, H Zhang, J Jiao, R Zhang… - Journal of Cell …, 2022 - rupress.org
… in cells results in decreased levels of several hundred proteins, these results support that
SARS-CoV-2 ORF10 may help explain some of the cilium-related clinical features of COVID-19…

Characterization and structural prediction of the putative ORF10 protein in SARS-CoV-2

NA Schuster - bioRxiv, 2020 - biorxiv.org
… found in the SARS-CoV lineage at nucleotide position 76. … the ORF10 protein within
SARS-CoV-2. Herein, this current study uses a bioinformatic approach to characterize this protein, …

SARS-CoV-2 ORF10 suppresses the antiviral innate immune response by degrading MAVS through mitophagy

X Li, P Hou, W Ma, X Wang, H Wang, Z Yu… - Cellular & molecular …, 2022 - nature.com
… In this study, we report the mechanism by which the SARS-CoV-2 ORF10 protein abrogates
antiviral innate immunity and facilitates viral replication (Fig. 7). Our findings indicate that …

The SARS-CoV-2 ORF10 is not essential in vitro or in vivo in humans

K Pancer, A Milewska, K Owczarek… - PLoS …, 2020 - journals.plos.org
… Here, we identified SARS-CoV-2 variants in which the ORF10 gene … ORF10 protein may
play a role in the immunogenicity of the SARS-CoV-2 or may modulate the virulence of the SARS

SARSCoV‐2 ORF10 antagonizes STING‐dependent interferon activation and autophagy

L Han, Y Zheng, J Deng, ML Nan, Y Xiao… - Journal of medical …, 2022 - Wiley Online Library
… screened 29 SARS-CoV-2-encoded viral proteins and discovered that ORF10 of SARS-CoV-2 …
In this study, we screened 29 SARS-CoV-2 proteins to identify which viral proteins affect …

Rare mutations in the accessory proteins ORF6, ORF7b, and ORF10 of the SARS-CoV-2 genomes

SS Hassan, PP Choudhury, B Roy - Meta Gene, 2021 - Elsevier
… Here (Table 1), we present the missense mutations of the three accessory proteins ORF6,
ORF7b, and ORF10 over the available 3080 SARS-CoV-2 genomes. Note that the mutation of …

Spectral and theoretical study of SARS-CoV-2 ORF10 protein interaction with endogenous and exogenous macroheterocyclic compounds

MO Koifman, AS Malyasova, YV Romanenko… - … Acta Part A: Molecular …, 2022 - Elsevier
… the SARS-CoV-2 accessory proteins ORF10SARS-CoV-2 ORF10 protein shows the highest
affinity for Chlorin, which binds hydrophobically to the alpha structured region of the protein

ORF10–Cullin-2–ZYG11B complex is not required for SARS-CoV-2 infection

EL Mena, CJ Donahue, LP Vaites, J Li… - Proceedings of the …, 2021 - National Acad Sciences
… of ORF10 is critical for it, we find no evidence that ORF10 is … its paralog ZER1 are dispensable
for SARS-CoV-2 infection in … of ORF10 with the endogenous CRL2 proteins CUL2 and …