The ORF3a protein of SARS-CoV-2 induces apoptosis in cells

Y Ren, T Shu, DI Wu, J Mu, C Wang, M Huang… - Cellular & molecular …, 2020 - nature.com
… S3), suggesting that the two ORF3a proteins from different … these two coronaviral proteins.
Our results showed that compared with those with SARS-CoV-2 ORF3a, SARS-CoV ORF3a

[HTML][HTML] Variations in Orf3a protein of SARS-CoV-2 alter its structure and function

GK Azad, PK Khan - Biochemistry and biophysics reports, 2021 - Elsevier
… variations among Orf3a proteins, Clustal Omega mediated multiple sequence alignments
(MSA) were performed between the Orf3a protein sequences among SARS-CoV-2 reported till …

SARS-Cov-2 ORF3a: mutability and function

M Bianchi, A Borsetti, M Ciccozzi… - International journal of …, 2021 - Elsevier
SARS-CoV-2 ORF3a protein during pandemic is reported. ORF3a, a conserved coronavirus
protein, is involved in virus … A set of 70,752 high-quality SARS-CoV-2 genomes available in …

The SARS-CoV-2 protein ORF3a inhibits fusion of autophagosomes with lysosomes

Y Zhang, H Sun, R Pei, B Mao, Z Zhao, H Li, Y Lin, K Lu - Cell discovery, 2021 - nature.com
… viral proteins of SARS-CoV-2 and identified that ORF3a strongly inhibited autophagic flux by
blocking the fusion of autophagosomes with lysosomes. ORF3a … fusion and protein sorting (…

Pathogenic perspective of missense mutations of ORF3a protein of SARS-CoV-2

SS Hassan, D Attrish, S Ghosh, PP Choudhury, B Roy - Virus Research, 2021 - Elsevier
… of ORF3a proteins will extend our knowledge of ORF3a, a vital accessory protein in SARS-CoV2,
which would assist to enlighten on the pathogenicity of this life-threatening COVID-19. …

SARS-CoV-2 and ORF3a: nonsynonymous mutations, functional domains, and viral pathogenesis

E Issa, G Merhi, B Panossian, T Salloum, S Tokajian - Msystems, 2020 - Am Soc Microbiol
proteins among 2,782 SARS-CoV-2 strains. We observed microclonality within the ORF3a
… We investigated the presence in SARS-CoV-2 of functional domains in the 3a protein linked …

Understanding the role of SARS-CoV-2 ORF3a in viral pathogenesis and COVID-19

J Zhang, A Ejikemeuwa, V Gerzanich, M Nasr… - Frontiers in …, 2022 - frontiersin.org
ORF3a, also must be considered. The purpose of this article is to review the current literature
on ORF3a, to summarize the molecular actions of SARS-CoV-2two SARS ORF3a proteins

ORF3a mutation associated with higher mortality rate in SARS-CoV-2 infection

P Majumdar, S Niyogi - Epidemiology & Infection, 2020 - cambridge.org
… get ORF3a (SARS-CoV-2) − human protein interactome. Our … of ORF3a protein between
SARS-CoV and SARS-CoV-2 thus con… pertinence of SARS-CoV-2 putative ORF3a protein from …

A novel diG motif in ORF3a protein of SARS-Cov-2 for intracellular transport

R Cruz-Cosme, J Zhang, D Liu, V Mahase… - Frontiers in Cell and …, 2022 - frontiersin.org
… Like what we showed in transfected cells (Figure 1A), the ORF3a proteins in those … the
ORF3a protein alone or in the context of viral infection showed that ORF3a protein of SARS-CoV-2

SARS-CoV-2 accessory proteins ORF7a and ORF3a use distinct mechanisms to down-regulate MHC-I surface expression

N Arshad, M Laurent-Rolle… - Proceedings of the …, 2023 - National Acad Sciences
proteins ORF7a and ORF3a of SARS-CoV-2 mediate this function and delineate the two
We expressed SARS-CoV-1 ORF3a or SARS-CoV-2 ORF3a proteins in HeLaM cells and …