… SARS-CoV- infected cells, the orf7a protein is expressed and retained intracellularly. Confocal
microscopy studies using orf7a and orf7a/… trafficking of the protein within the endoplasmic …

… shown that the ORF3a, M, ORF7a, and N proteins of SARS-CoV-2 do not directly inhibit
nor … , ORF7a protein induced the production of IFNβ mRNA (Fig. 4A), indicating that ORF7a …

… We report that the accessory proteins ORF7a and ORF3a of SARS-CoV-2 mediate this …
While ORF3a inhibits global protein trafficking to the cell surface, ORF7a acts specifically on MHC-…

… Previously, we and others have confirmed the expression of ORF7a in SARS-CoV infected
cells;4–6 however, there is a discrepancy in the subcellular localization ascribed to the …

… ORF7a stop codon in a −1 shifted ORF. We demonstrate that the ORF7b protein is expressed
in virus… the protein has biochemical properties consistent with that of an integral membrane …

… SARS-CoV-2 usurps the host ubiquitin system to polyubiquitinate accessory protein ORF7a
… Collectively, we show for the first time that SARS-CoV-2 ORF7a usurps the host ubiquitin …

… like fold ectodomain of the viral protein SARS-CoV-2 ORF7a interacts with high efficiency to
… to pathogenic protein SARS-CoV ORF7a. The crystal structure of SARS-CoV-2 ORF7a at 2.2 …

… shares 85.2% identity and 95.9% sequence similarity with ORF7a protein from SARS-CoV
(7). ORF7a is another SARS-CoV-2 protein with the ability to antagonize the IFN-I response (…

… In addition, we demonstrate that SARS-CoV-2 ORF7a, a SARS-CoV-2 accessory protein,
counteracts the antiviral effect of SERINC5. SARS-CoV-2 ORF7a counteracts SERINC5 by …

… In this study, we demonstrate that overexpression of the SARS-CoV-2 ORF7a protein …
of the viral ORF7a gene via shRNAs targeting ORF7a sgRNA during SARS-CoV-2 infection …