Unspecific post-mortem findings despite multiorgan viral spread in COVID-19 patients

M Remmelink, R De Mendonça, N D'Haene… - Critical care, 2020 - Springer
… heterogeneity of COVID-19-associated organ injury and the remarkable absence of any
specific viral lesions, even when RT-PCR identified the presence of the virus in many organs. …

Transmission routes analysis of SARS-CoV-2: a systematic review and case report

H Li, Y Wang, M Ji, F Pei, Q Zhao, Y Zhou… - Frontiers in cell and …, 2020 - frontiersin.org
… The global outbreak of SARS-CoV-2 spread rapidly throughout the world … damage host
organs and tissues. In the early stages of … pathways and susceptible organs of the SARS-CoV-2. …

[HTML][HTML] New understanding of the damage of SARS-CoV-2 infection outside the respiratory system

Y Zhang, X Geng, Y Tan, Q Li, C Xu, J Xu, L Hao… - Biomedicine & …, 2020 - Elsevier
… It can be inferred that SARS-CoV-2 can spread to other organs except the lungs through
the … all organs. Therefore, once in the circulatory system, SARS-CoV-2 is likely to spread via …

Organ-specific genome diversity of replication-competent SARS-CoV-2

J Van Cleemput, W van Snippenberg… - Nature …, 2021 - nature.com
COVID-19 patients, including multi-organ failure. Besides, multiple studies have found traces
of SARS-CoV-2 (ie, viral RNA and proteins or virusdissemination of infectious SARS-CoV-2

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2): a systemic infection

A Synowiec, A Szczepański… - Clinical microbiology …, 2021 - Am Soc Microbiol
… of the virus confirms that SARS-CoV-2 may be spread either … the intercellular dissemination
of SARS-CoV-2 in this organ. … damage to the blood-brain barrier in order to disseminate into …

SARS-CoV-2 cell tropism and multiorgan infection

J Liu, Y Li, Q Liu, Q Yao, X Wang, H Zhang, R Chen… - Cell discovery, 2021 - nature.com
… that SARS-CoV-2 infection in the vascular endothelial cells of various organs induces both
direct and indirect damage … that might represent a dissemination route within the human body. …

SARS-CoV-2, ACE2 expression, and systemic organ invasion

UM Ashraf, AA Abokor, JM Edwards… - Physiological …, 2021 - journals.physiology.org
damage islets, which may cause acute insulin-dependent DM (71). Although further evidence
is needed, pancreatic damage may also be present in patients with COVID-19, … to spread

SARS-CoV-2 pathogenesis

MM Lamers, BL Haagmans - Nature reviews microbiology, 2022 - nature.com
… respiratory tract and cause alveolar damage as a result of … can spread to the lower respiratory
tract by inhalation of virusCOVID-19 is an inflammatory disease affecting many organs, …

STAT2 signaling restricts viral dissemination but drives severe pneumonia in SARS-CoV-2 infected hamsters

R Boudewijns, HJ Thibaut, SJF Kaptein, R Li… - Nature …, 2020 - nature.com
… On the indicated days post inoculation (pi), organs and blood … organs were quantified by
RT-qPCR (b, d–f) or virus titration (… -2 and IP-10 and failure to respond to SARS-CoV-2 infection …

Inflammation triggered by SARS-CoV-2 and ACE2 augment drives multiple organ failure of severe COVID-19: molecular mechanisms and implications

M Iwasaki, J Saito, H Zhao, A Sakamoto, K Hirota, D Ma - Inflammation, 2021 - Springer
organ injuries and failure and the underlying mechanisms of COVID-19 that are associated
with SARS-CoV-2 … ; these small infection clusters had spread throughout the entire organoids …